Copper(II) and nickel(II) complexes of 2-formylpyridine 3-piperidinyl-, 3-hexamethyleneiminyl- and 3-azabicyclo[3.2.2]nonylthiosemicarbazones

Abstract

Copper(II) and nickel(II) complexes of 2-formylpyridine 3-piperidinyl-, 3-hexamethyleneiminyt-and 3-azabicyclo-I-3.2.2]nonylthiosemicarbazones were prepared and characterized spectroscopically. 1H and ~3C n.m.r, spectra of the thiosemicarbazones and a diamagnetic nickel(II) complex are reported, together with i.r., electronic and e.s.r. spectra of the metal complexes. The thiosemicarbazones and their copper(II) and nickel(II) complexes exhibit considerable growth inhibitory activity against Paecilomyces variotii, but show minimal activity against Aspergillus niger.

Structural Study of Nickel(II), Copper(II), and Palladium(II) Complexes of 2-Pyridineformamide 3-Hexamethyleneiminylthiosemicarbazone

“…Compared to HAmhexim, which has the bifurcated hydrogen bonded E' structure [14], [Ni(Amhexim)OAc] has a longer S1ϪC17 bond, 1.757(7) Å to 1.732(4) Å and N13ϪC17 is shorter, 1.308(6) Å compared to 1.330(5) Å , but C16ϪN12 is unchanged. These changes are similar to those found for complexes of 2-acetylpyridine 3-hexamethyliminylthiosemicarbazone [22], which also has the bifurcated structure, but considerably smaller than found for the 2-formyl- [1] and 2-benzoylpyridine analogues [3], which have the hydrogen bonded Z conformation.…”

Synthesis and Structural Characterization of Metal Complexes of 2-Formylpyrrole-4N-ethylthiosemicarbazone (4 EL1) and 2-Acetylpyrrole-4N-ethylthiosemicarbazone (4 EL2)

“…In the spectra of 10±13 coordination via the azomethine nitrogen atom is suggested by the appearance of a new band attributable to m(M±N) near 350 cm ±1 . The metal-halogen stretching bands have been identified on the basis of the literature [35,36] and in view of the ratios m(M±Br)/ m(M±Cl) = 0.74±0.77 and m(M±I)/m(M±Cl) = 0.65 that hold in other cases [23,24,28,37].…”

Coordination of ZnII, CdII, and HgII by 2-Pyridineformamide-3-piperidyl-thiosemicarbazone

“…2-Formyl-, 2-acetyl-, and 2-benzoylpyridine N(4)-substituted thiosemicarbazones [9][10][11] possess substantial in vitro activity against various human tumor lines [12]. Their lack of solubility in aqueous solutions makes these thiosemicarbazones and their complexes less promising for in vivo testing.…”