Titania is obtained by taking titanium oxysulfate sulfuric acid complex hydrate as Ti source with a simple, energy saving process. The effect of hydrothermal time and temperature on morphology is investigated. The particle size and morphology are analyzed by X-Ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Additionally, the effect of tetracycline/TiO 2 ratio on drug loading capacity and encapsulation rate are studied. Zero-order kinetics, first-order kinetic, and Higuichi kinetic models are employed to investigate the drug release kinetics. The morphology of as-prepared TiO 2 treated with hydrothermal temperature of 120 C for 0.5 h is most regular, presents microsphere shape which is composed of small particles with size of 19.36 nm and shows high drug loading capacity (32.25 AE 0.46%) and high encapsulation rate (47.63 AE 1.41%) due to the large specific surface area of 91.0629 m 2 g À1 , and it fits well with Higuichi equation with the correlation coefficients of 0.96981, illustrating that TiO 2 has sustained release function. Therefore, this paper provides a convenient route to prepare TiO 2 with good performance.
In this paper, chitosan/hydroxyapatite (CS/n-HA) were synthesized by ultrasound-assisted precipitation combined with inverse crosslinking-emulsion method. In order to obtain a scaffold material with excellent properties, Calcium sulfate hemihydrate (CSH) were combined with CS-HA obtained CSH/CS/n-HA composite scaffold via setting citric acid as solidifying liquid, which possessed better biodegradability, bioactivity, mechanical properties. The physicochemical, morphological properties of scaffolds were characterized by FTIR, XRD and TFSEM. In addition, explored were the mechanical, degradable, biocompatibility and iron release properties. The mechanical strength study indicated that the compressive strength of the porous composite scaffold was influenced by adding an appropriate amount of CS/n-HA composite microspheres. It was proved that the composite scaffold with 6% CS/n-HA content obtained the highest mechanical strength (17.46±1.29 MPa). The results illustrated that the composite scaffold possessed biodegradability and can form hydroxyapatite by dynamic balance of Ca and P elements. The hemolysis tests demonstrate that materials are non-hemolytic and have good blood compatibility. Therefore, the developed composite scaffolds are safe medical inorganic materials, which can potentially be applied in bone tissue engineering.
Nano-hydroxyapatite(nHAp) powders were prepared by chemical precipitation method using Ca(NO3)2·4H2O and (NH4)2HPO4 as raw materials and deionized water as solvent. To investigate the influence of ageing time on the preparation of nano HAp powder by changing the ageing time. And the composition and appearance of the samples were analyzed by infrared spectroscopy (FTIR), X ray diffraction (XRD) and scanning electron microscopy (SEM). With the longer ageing time, the samples gradually became sphere-like crystals and the crystallization degree were better.
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