The applications of thioureas in crystal engineering have increased dramatically over the past few years. However, their analogs namely N-imino thioureas/thiosemicarbazones are largely ignored, despite the fact that these can be more interesting with respect to crystal engineering applications due to the presence of an additional N-imino moiety. Aiming to highlight their importance in crystal engineering/ supramolecular chemistry, three structurally related coumarin-thiosemicarbazone hybrids (3a-3c) have been designed, synthesized and crystallographically characterized. All of the compounds showed a general preference for the adoption of the cis, trans conformation around the central thiourea moiety; a conformation which is ideal for the formation of a dimeric hydrogen-bonded R 2 2 (8){Á Á ÁH-N-CQS} 2 synthon as the building block. Therefore, this dimeric synthon is observed in all of the compounds, regardless of the formation of layered to cage-like three dimensional supramolecular networks depending on different substituents. The prevalence of the cis, trans conformation and the robustness of the thioamide dimer synthon in thiosemicarbazones indicate its potential use as a design element in crystal engineering.
The role of thioureas in crystal engineering as robust supramolecular synthons is now recognized, but their analogs, namely thiosemicarbazones/N-iminothioureas, have not received the attention they deserve.
Several neurological disorders, including Parkinson's disease, schizophrenia, human immunodeficiency virus infection, and restless leg syndrome, majorly result from disruption in the dopamine (DA) level.
Herein,
we synthesized hollow cubic caves of CuO (HC) and wrapped
it with N-rich graphitic C (NC), derived from a novel biogenic mixture
composed of dopamine (DA) and purine. The synthesized NC wrapped HC
(NC@HC) sensor shows enhanced electrocatalytic efficacy compared to
unwrapped CuO with shapes including HC, sponge (SP), cabbage (CB),
and solid icy cubes (SC). The shape and composition of synthesized
materials were confirmed through field-emission scanning electron
microscopy (FE-SEM), X-ray diffraction (XRD), Raman spectroscopy,
and X-ray photoelectron spectroscopy (XPS), whereas interfacial surface
energy was calculated through contact angle measurement. The designed
NC@HC sensor shows a remarkable response toward the simultaneous detection
of uric acid (UA) and xanthine (Xn) with detection limits of 0.017
± 0.001 (S/N of 3) and 0.004 ± 0.001 μM (S/N of 3),
respectively. In addition, this platform was successfully applied
to monitor UA from the gout patient serum. To the best of our knowledge,
this is the first report on using such novel NC@HC materials for the
simultaneous monitoring of UA and Xn.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.