Carbon-dot wrapped ZnO nanoparticle-based photoelectrochemical sensor for selective monitoring of H2O2 released from cancer cells

Khan, Faria; Akhtar, Naeem; Jalal, Nasir; Hussain, Irshad; Szmigielski, Rafał; Hayat, Muhammad Qasim; Ahmad, Hafiz Badaruddin; El‐Said, Waleed A.; Yang, Minghui; Janjua, Hussnain Ahmed

doi:10.1007/s00604-019-3227-x

Cited by 39 publications

(13 citation statements)

References 35 publications

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“…The LOD was measured using a previously reported method (eq S1). 42 The limit of quantification (LOQ) was also calculated (eqs S2), and observed to be 0.51 and 0.0123 μM, respectively for UA and Xn at the NC@HC electrode. Similarly, the linear range and sensitivity were found to be 50−1050 and 05−90 μM and 1.47 and 14.84 μA/μM, respectively for both UA and Xn.…”

Section: Controlled Shape Patterns Of Synthesizedmentioning

confidence: 99%

CuO Hollow Cubic Caves Wrapped with Biogenic N-Rich Graphitic C for Simultaneous Monitoring of Uric Acid and Xanthine

Hayat

Munawar

Zulfiqar

et al. 2020

ACS Appl. Mater. Interfaces

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Herein, we synthesized hollow cubic caves of CuO (HC) and wrapped it with N-rich graphitic C (NC), derived from a novel biogenic mixture composed of dopamine (DA) and purine. The synthesized NC wrapped HC (NC@HC) sensor shows enhanced electrocatalytic efficacy compared to unwrapped CuO with shapes including HC, sponge (SP), cabbage (CB), and solid icy cubes (SC). The shape and composition of synthesized materials were confirmed through field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS), whereas interfacial surface energy was calculated through contact angle measurement. The designed NC@HC sensor shows a remarkable response toward the simultaneous detection of uric acid (UA) and xanthine (Xn) with detection limits of 0.017 ± 0.001 (S/N of 3) and 0.004 ± 0.001 μM (S/N of 3), respectively. In addition, this platform was successfully applied to monitor UA from the gout patient serum. To the best of our knowledge, this is the first report on using such novel NC@HC materials for the simultaneous monitoring of UA and Xn.

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Section: Controlled Shape Patterns Of Synthesizedmentioning

confidence: 99%

CuO Hollow Cubic Caves Wrapped with Biogenic N-Rich Graphitic C for Simultaneous Monitoring of Uric Acid and Xanthine

Hayat

Munawar

Zulfiqar

et al. 2020

ACS Appl. Mater. Interfaces

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“…It shows that our LOD is lower than the ones obtained on BiVO 4 , Si, CuO and CdS‐based photoelectrodes. In addition, our linear range, which spans 2 orders of magnitudes in concentration, is large and greater than the ones reported for TiO 2 , WO 3 , ZnO and Cu 2 O‐based photoelectrodes. It is also interesting to note that systems based on the TiO 2 /CdS heterojunction exhibit a lower LOD and a wide linear range, however, these systems may have disadvantages from an environmental point of view.…”

Section: Figurementioning

confidence: 56%

“…So far, PEC sensing has been mainly employed for the detection of biological macromolecules, in immuno‐ or apta‐ assays and has also been explored for the detection of small organic molecules such as antioxidants or glucose . While H 2 O 2 is a widely‐employed hole scavenger in the field of energy‐related photoelectrochemical research (typically used to probe the upper performance of water‐splitting photoanodes), the PEC sensing of H 2 O 2 has been only reported on TiO 2 , WO 3 , ZnO, BiVO 4 , and Si‐based photoanodes and on Cu 2 O, CuO, CdS, and CuInS 2 ‐based photocathodes.…”

Section: Figurementioning

confidence: 99%

Photoelectrochemical Sensing of Hydrogen Peroxide on Hematite

et al. 2020

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Due to its abundance and chemical stability, hematite (α‐Fe2O3) is a promising n‐type semiconductor photoelectrode. This is particularly true in the frame of the rapidly developing area of photoelectrochemical (PEC) sensing, where the short excited‐state lifetime and the small carrier diffusion length of hematite can be beneficially employed. On the other hand, H2O2 is an essential molecule for biological, environmental and industrial applications. In this article, we report a simple method to prepare photoelectroactive hematite layers on fluorine‐doped SnO2 (FTO) and we use these surfaces for H2O2 PEC sensing. The so‐created sensors allow to reliably detect H2O2 down to a sub‐μM concentration with a large linear range and a good reusability.

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“…Besides, monitoring the critical biomarkers in the human body represented an essential basis for health assessment, pharmaceutical guidance, surgical intervention protocols, and postsurgical monitoring (Khan et al, 2019 ; Li et al, 2020 ; Patella et al, 2021 ). Nowadays, there is a high interest in developing efficient strategies to diagnose cancer and fight against it.…”

Section: Nanopatterned Surface To Detect Cellular State and Chemicals Based On Electrochemical Techniquesmentioning

confidence: 99%

Electrochemical Cell Chips Based on Functionalized Nanometals

El‐Said

Yoon

Lee³

2021

Front. Chem.

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The electrochemical technique is one of the most accurate, rapid, and sensitive analytical assays, which becomes promising techniques for biological assays at a single-cell scale. Nanometals have been widely used for modification of the traditional electrodes to develop highly sensitive electrochemical cell chips. The electrochemical cell chips based on the nanostructured surface have been used as label-free, simple, and non-destructive techniques for in vitro monitoring of the effects of different anticancer drugs at the cellular level. Here, we will provide the recent progress in fabrication of nanopatterned surface and cell-based nanoarray, and discuss their applications based on electrochemical techniques such as detection of cellular states and chemicals, and non-destructive monitoring of stem cell differentiation.

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Carbon-dot wrapped ZnO nanoparticle-based photoelectrochemical sensor for selective monitoring of H2O2 released from cancer cells

Cited by 39 publications

References 35 publications

CuO Hollow Cubic Caves Wrapped with Biogenic N-Rich Graphitic C for Simultaneous Monitoring of Uric Acid and Xanthine

CuO Hollow Cubic Caves Wrapped with Biogenic N-Rich Graphitic C for Simultaneous Monitoring of Uric Acid and Xanthine

Photoelectrochemical Sensing of Hydrogen Peroxide on Hematite

Electrochemical Cell Chips Based on Functionalized Nanometals

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