A new five-coordinated diorganotin(IV) complex with formula Sn(CH 3 ) 2 Cl 2 L (L = (C 6 H 5 ) 2 (O)P(NHC 6 H 11 )), with a rod-shaped nanostructure, was synthesized using a sonochemical method. The nanostructure was characterized using various techniques. The bulk complex was also produced using a reflux method applied to a solution of the reagents. The ligand and bulk form were characterized using 1 H NMR, 13 C NMR, 31 P NMR, 119 Sn NMR, UV-visible and infrared spectroscopies. By direct calcination of the synthesized complex at 650°C, nanopowders were obtained with spherical-like structure and diameters of 40-100 nm (for bulk form) and 20-60 nm (for nanometric form). Two different forms of Sn(IV) complex (C 1 , C 2 ) and the corresponding ligand were evaluated regarding their anticancer activity, as well as their influence on both Gram-positive and Gram-negative classes of bacteria. Among the compounds, nanostructured C 2 was found to be the most active with IC 50 of 62 ± 0.03 and 92 ± 0.09 μM against A2780 and PC-3 cell lines. Preliminary antibacterial experiments were carried out using the cup test method, in which nanocomplex C 2 showed better activity against all the selected bacteria than other compounds. Moreover, single crystals of C 3 were obtained by the interaction of (CH 3 ) 2 Cl 2 Sn with L in ethanol-water solution, where the Sn(IV) ion is six-coordinated with one-dimensional polymeric chains. The intermolecular interactions which connected the chains into a two-dimensional framework were supported by Hirshfeld surface analysis and fingerprint plots.
Introduction: Nowadays, cancer is known as one of the major problems of human society and scientists and researchers are looking for short and very effective ways to identify and treat this group of diseases. One of these ways to investigate specific genes in pathways that can be used to identify cancer-specific biomarkers, containing expression FAT4 and NAT2 in breast cancer and the effect on the signaling pathway in human cells. Because of the comparison high frequency of some FAT4 and NAT2 genotypes in the population, the Attributable cancer risk might be high. The effect of FAT4 and NAT2 genotype on cancer risk varies with organ location, maybe reflecting tissue-specific expression of FAT4 and NAT2. Materials and Methods: Here we took 25 tumor samples and adjacent normal tissue of Iran National tumor Bank, we found the up regulation FAT4 and down regulation NAT2. Results: There is no evidence for the relation between FAT4 and NAT2 (P>0.05).
Conclusions:The results propose there is an interaction between FAT4 genotype with P53 signaling pathway (P <0.05).
Original Article
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