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Torabinejad M, Moazzami SM, Moaddel H, Hawkins J, Gustefson C, Faras H, Wright K, Shabahang S. Effect of MTA particle size on periapical healing. International Endodontic Journal, 50, e3-e8, 2017.Aim To examine the effect of reduction in MTA particle size on dento-alveolar and osseous healing in dogs. Methodology Root canals of 24 mandibular premolars in four 2-year-old beagles were prepared and filled with gutta-percha and sealer. Two to four weeks later, during periapical surgery, the root-end cavity preparations in these teeth were filled with either grey ProRoot MTA or modified (reduced particle sizes with faster setting time) MTA. The animals were sacrificed 4 months later. Degrees of inflammation, type of inflammatory cells, fibrous connective tissue adjacent to the root-end filling materials, cementum formation over the resected roots and root-end filling materials and bone healing were examined. Data were analysed using the McNemar test.Results No significant differences in healing of periapical tissues were found when comparing ProRoot MTA to a modified MTA containing reduced particle sizes. Conclusion Reducing the particle sizes of MTA did not impact its biological properties.