A Clinical and Histological Report of a Tooth with an Open Apex Treated with Regenerative Endodontics Using Platelet-rich Plasma

Torabinejad, Mahmoud; Faras, Hadi

doi:10.1016/j.joen.2012.03.006

Cited by 133 publications

(94 citation statements)

References 32 publications

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“…In recent years, PRP has been widely used in such clinical treatment fields as orthopedics, oral cavity dental implantation, and regeneration of the periodontium (Kim et al, 2010;Torabinejad and Faras, 2012). At present, most reports of animal experimental and clinical research have found that PRP is able to significantly promote the healing of hard and soft tissues and the regeneration of osseous tissues (Khorsand et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

2015

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ABSTRACT. We examined the effects of washed platelets (WPLTs) and platelet-rich plasma (PRP) on the proliferation and mineralization of rat dental pulp cells. Rat dental pulp cells were separated, cultured, and identified. Medium containing 1, 10, 100, or 500 mL/L PRP or WPLTs was added to 4th generation cells. The MTS method was used to determine cell proliferation. Alizarin red staining was used to observe the formation of mineralized nodules after cell mineralization and induction for 10 and 20 days under different culture conditions, and the areas of the mineralized nodules formed 20 days after induction were computed. The addition of 1, 10, and 100 mL/L WPLTs or PRP significantly promoted rat dental pulp cell proliferation (P < 0.05) whereas 500 mL/L WPLTs or PRP had no significant effect (P > 0.05). Under the same concentrations, no significant differences on cell proliferation were observed between WPLT and PRP treatments (P > 0.05 in all groups). After 10 days mineralization and culture, the 100 and 500 mL/L WPLT and PRP group positive nodule rates were significantly higher than those of the low concentration and the control groups (P < 0.05). After 20 days, the areas of the mineralized nodules formed in the 100 and 500 mL/L WPLT and 9487 Effects of WPLTs and PRP on rat dental pulp cells ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9486-9496 (2015) PRP groups were significantly larger than those in the control group (P < 0.05). These results demonstrate that both WPLTs and PRP are equally able to significantly promote the proliferation and calcification of rat dental pulp cells under a certain range of concentrations.

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Section: Discussionmentioning

confidence: 99%

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

2015

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“…However, the number of reports on in vivo teeth that have undergone regenerative endodontics followed by histological analysis is scarce. Of those reported, four teeth were extracted due to orthodontic reasons and 24,[35][36][37] three fractured and were extracted, 23,38,39 and in the remaining studies, one tooth was extracted due to recurrence of infection after treatment, 40 another patient requested a root canal filling, 41 and one study evaluated mature teeth. 42 These reports may not be representative of the histological conditions in those cases where regenerative endodontics have been successful.…”

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confidence: 99%

Histological assessment of regenerative endodontic treatment in animal studies with different scaffolds: A systematic review

Altaii

Richards

Rossi‐Fedele

2017

Dental Traumatology

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“…There are several reports in the literature on the histologic outcome of pulp regeneration in human teeth (71)(72)(73). In 1 of them (73), vital pulplike connective tissue was found in the root canal of a tooth treated 14 months previously with a regenerative endodontic procedure using platelet-rich plasma.…”

Section: Dentin Regeneration Versus Repair With Other Types Of Mineramentioning

confidence: 99%

Healing after Regenerative Procedures with and without Pulpal Infection

Fouad

Verma

2014

Journal of Endodontics

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A Clinical and Histological Report of a Tooth with an Open Apex Treated with Regenerative Endodontics Using Platelet-rich Plasma

Cited by 133 publications

References 32 publications

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

Histological assessment of regenerative endodontic treatment in animal studies with different scaffolds: A systematic review

Healing after Regenerative Procedures with and without Pulpal Infection

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