Mutations in the gamma-aminobutyric acid type A receptor (GABRG2) gene have been associated with generalized epilepsy, childhood absence epilepsy and febrile seizures. In the present study the authors investigated the association of polymorphism of the GABRG2 with simple febrile seizures (FS) in Egyptian children. Polymorphism at GABRG2 (SNP211037, Asn196Asn), on chromosome 5q33 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 100 Egyptian children with simple FS, and 120 healthy controls. The frequency of CC genotype of GABRG2 gene was significantly higher in children with simple FS compared to healthy children (p  ≤  0.0001). The C allele of GABRG2 was associated with increased risk for developing simple FS (OR: 2.15. 95% CI, 1.4-3.2. p  ≤  0.0001). The present findings suggested that the GABRG2 (SNP211037)-C allele could be a suitable genetic marker for prediction of susceptibility to simple FS in Egyptian children.

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BackgroundSomatization in children consists of the persistent experience and complaints of somatic distress that cannot be fully explained by a medical diagnosis. The aim of this study was to determine the prevalence and risk factors of unexplained somatic symptoms and their relation to emotional symptoms in school-aged children. Participants and methodsThe sample included 294 children recruited from four primary schools of Sharkia Governorate. All the children were between 6 and 12 years of age, were from both sexes, and had no social limitation. All participants were subjected to psychiatric assessment for somatic symptoms by the Children's Somatization Inventory. They were also assessed for depression by the Child Depression Inventory and for anxiety by the Revised Children's Manifest Anxiety Scale. ResultsThe prevalence rate of somatic symptoms was 13%, that of depression was 9%, and that of anxiety was 21%. Somatic symptoms were correlated with emotional symptoms. ConclusionThis study concluded that there was a high rate of somatic and emotional symptoms in school children that were interrelated with sociodemographic characteristics.

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Background: After 48 hours of phototherapy, the mean urinary Ca excretion is elevated in numerous neonates in previous studies.Objective: This study aimed to evaluate phototherapy effects on urinary calcium excretion among full term neonates. Patients and methods: This Prospective-cohort study was conducted on 30 term neonates presented in NICU of Pediatrics Department, Zagazig University Hospitals through the period from January 2018 to January 2019. They were exposed to phototherapy. We assessed urinary calcium and sodium excretion post-phototherapy in term neonates. Results: As regards urinary calcium, our results revealed an increment in urinary calcium excretion of about 8.76% post-phototherapy exposure, which was significantly increased after phototherapy. A statistically significant increment in serum sodium after exposure to phototherapy was found. Considering urinary calcium, there was statistically significant increase in urine calcium after phototherapy in female patients aged ≥ 8 days born at gestational age less than 39 week and in those delivered by cesarean section. On the other hand, there was statistically significant decrease in calcium/creatinine ratio after phototherapy in patients delivered by cesarean section only Conclusion: Despite presence of an increment in urinary calcium excretion after phototherapy, no significant difference was found in calcium/creatinine ratio after phototherapy, so no hypercalciuria to be considered, so it cannot cause hypocalcemia.