Impact of glutathione-S-transferase gene polymorphisms on enzyme activity, lung function and bronchial asthma susceptibility in Egyptian children

The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke

“…They did not find any difference in GST activities and did not find any associations between gene polymorphisms and the risk of stroke. However, in hypertensive stroke patients, they found about five times for GSTT1 and two times for GSTM1 higher stroke risk as compared to the controls [12]. Wang et al also did not find any significant differences between patients and controls.…”

“…These gene depletions result in loss of enzymatic activity and may alter the development of stroke in subjects in terms of their genotypes. Based on the fact that common homozygote deletion polymorphisms of the GSTM1 and GSTT1 and GSTP1Ile105Val gene polymorphisms have been known to abolish enzyme activity and increase susceptibility of oxidative stress [12]. Stroke patients who present lower GST activity might be a susceptibility factor for oxidative stress injury [13] [14,15,16].…”

Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis

“…Activated PAHs in the human body are detoxified by phase II enzymes such as glutathione S-transferase M1 (GSTM1), which makes PAH metabolites, such as 1-OHP, more water soluble and suitable for excretion [21]. Glutathione S-transferase M1 has well-defined null and active genotypes, and it has been reported that the null GSTM1 genotype causes a homozygous deletion that could result in functional loss of this enzyme [22]. Hence, the ability of null GSTM1 carriers to eliminate PAH metabolites is reduced; therefore, for individuals with this genotype, the PAH biomarker levels are generally higher [23].…”

Quantitative Assessment of the Association Between the GSTM1-Null Genotype and the Risk of Childhood Asthma

“…One study contained four case-control studies from different ethnicities (Gilliland et al, 2002), and two studies contained two individual case-control studies, respectively (Kamada et al, 2007;Minelli et al, 2010). Finally, 19 casecontrol studies from 14 publications with 4,543 childhood asthma cases and 19,394 controls were included into this meta-analysis (Vavilin et al, 2000;Gilliland et al, 2002;Kabesch et al, 2004;Lee et al, 2005;Ercan et al, 2006;Hanene et al, 2007;Kamada et al, 2007;Li et al, 2009;Henderson et al, 2010;Lima et al, 2010;Minelli et al, 2010;Tung et al, 2011;Karam et al, 2012;Piacentini et al, 2012). Among those 19 case-control studies, 8 (75.0%) were from Caucasian populations, and 6 (12.5%) were from Asians and 3 from Africans (Table 1).…”