The flexible metal-organic frameworks (MOFs) materials, also called soft porous crystals which combine the crystalline order of the underlying coordination network with cooperative structural transformability, have been extensively studied as promising materials for various applications such as sensing, drug delivery, catalysis, host-guest complex etc. Among them MOFs is effectively used as a carrier for drug delivery. Herein, a flexible metal-organic framework MIL-53(Fe) functionalized with polyethyleneglycol (PEG) was successfully fabricated by ultrasonication. The prepared material was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), transmittance electron microscopy (TEM), Brunauer-Emmett-Teller (BET) surface area and infrared spectroscopy (IR). The effect of the PEG content on the morphology and particles size of the MIL-53 was investigated in detail. The resultant flexible MIL-53(Fe)-PEG materials were seen to be homogeneous with the morphology of hexagonal bipyramidal structure, approximately 700 nm in length and 400 nm in diameter. Furthermore, we investigated loading of 5-fluorouracil (5-FU) drug and its release in vitro conditions by employing MIL-53(Fe)-PEG. The results showed that in vitro condition, only 31% of the drug released after 3 h, and released completely after approximately 6 days. Thus, we believe that use of MIL-53(Fe)-PEG may overcome current issue of sustain release.[a] Prof.
Porphyrin nanostructures with well-controlled size, shape and functionality can be used for visible-light photocatalysis. In this work, a graphene@porphyrin nanofibre composite was successfully fabricated via arginine-mediated self-assembly of tetrakis (4-carboxyphenyl) porphyrin (TCPP) on graphene nanoplates (GNPs). The formation and crystallisation of the graphene@porphyrin nanofibre composite was fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), fourier transform infrared (FTIR), ultraviolet-visible (UV-vis) and fluorescence spectroscopy. The assembled TCPP nanofibers were 50-200 nm in diameter with length in micrometers long, which were densely and uniformly distributed on the surface of graphene. The GNPs@TCPP nanofibers showed enhanced visible-light photocatalytic activity in comparison with free-standing TCPP nanorods for the degradation of Rhodamine B (RhB) and methyl orange (MO). The possible photodegradation mechanism of these dyes by the GNPs@TCPP nanofiber photocatalyst was proposed.
The porous metal–organic
complexes are emerging as novel
carriers for effective and safe delivery of drugs for cancer treatment,
minimizing the side effect of drug overuse during cancer treatment.
This study fabricated the Fe–BTC–PEG metal–organic
complex from Fe ions, trimesic acid, and poly(ethylene glycol) as
precursors using an ultrasonic-assisted method. The morphology and
crystallinity of the resultant complex were observed by scanning electron
microscopy (SEM) and X-ray diffraction (XRD), respectively. FTIR spectroscopy
was employed to investigate the functional groups on the surface of
the Fe–BTC–PEG complex. The result showed that the prepared
Fe–BTC–PEG complex was in particle form with low crystallinity
and diameter ranging from 100 to 200 nm. The obtained Fe–BTC–PEG
complex exhibited a high loading capacity for the 5-fluorouracil (5-FU)
anticancer drug with a maximal capacity of 364 mg/g. The releasing
behavior of 5-fluorouracil from the 5-FU-loaded Fe–BTC–PEG
complex was studied. Notably, the acute oral toxicity of the Fe–BTC–PEG
metal–organic complex was also carried out to evaluate the
safety of the material in practical application.
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