Here, we report a case of 24-year-old female who experienced fever, weight loss, and headache by the termination of her pregnancy after 24 weeks. She was admitted due to multiple generalized tonic clonic (GTC) seizures and loss of consciousness. Her lab data and histological findings were insignificant as well as negative mycobacterium culture. Her brain MRI detected multiple enhanced brain lesions on T2 weighted images. Overall, she went under empiric anti-TB treatment for a year and had a complete recovery. To our knowledge, this is the first reported case of brain tuberculoma with negative histological findings and brain tissue culture who responded to an empiric anti-TB regimen.
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