Perinatal period spans from conception till one-year post-partum. Pregnancy and post-partum is characterised by significant biological changes in a woman's body including changes in blood pressure, blood volume, coagulability of blood and changes in immunity causing onset or relapse of certain medical and neurological conditions, which can face diagnostic and treatment challenges during this period. We aim to present a series of 3 cases which presented with psychiatric symptoms but on further evaluation were found to have neurological diagnosis-Cavernous Venous Thrombosis [CVT], Posterior Reversible Encephalopathy Syndrome [PRES] & Tuberculoma.