Article Information In the present study, In vitro anticancer effects of Euphorbia hirta were investigated. The objectives of this study are to find the presence of secondary metabolites by preliminary phytochemical investigation and FTIR analysis in the Euphorbia hirta. Ethanolic leaf extract of Euphorbia hirta was tested for its cytotoxicity against Dalton Lymphoma Ascites (DLA) and Ehrlich Ascites Carcinoma (EAC) cell lines using preliminary screening technique (Trypan Blue method and standard MTT colorimetric method). The Euphorbia hirta leaf extract was found to be more cytotoxic against Ehrlich Ascites Carcinoma cell lines when compared to cytotoxic activity against Dalton Lymphoma Ascites cell lines where as 59.67% cytotoxicity were noticed against Ehrlich Ascites Carcinoma cell lines. Extract of Euphorbia hirta showed a dose-dependent reduction of proliferation and induction of apoptosis in the Carcinoma cell lines cells. Ethanolic leaf extract of Euphorbia hirta showed potent cytotoxic activity against DLA and EAC cell lines and its IC50 value was found to be 560.83μg/ml and 384.7 μg/ml of extract respectively. The in vitro outcomes of Euphorbia hirta extract showed potent anticancer effect against both DLA and EAC cell lines.
Indigofera tinctoria L has long been traditionally employed for various diseases, including pain and inflammation. The present study is an attempt to evaluate the potential anti activity of Indigofera tinctoria L. The antiarthritic activity for petroleum ether and ethanol extracts (100, 200 and 300 mg/kg) of Indigofera tinctoria Freunds Complete Adjuvant (FCA) at the tibiotorsal joint. permeability, histamine, hematological parameters, ESR, evaluation of development of arthritis, biochemical parameters, and Interleukin (IL) Spleen cells (MTT assay), Radiographic analysis and histopathological assessments were carried out. The petroleum ether and ethanol extracts of anti-arthritic activity, by significant changes in the behavior permeability, histamine level, IL and TNF, proliferation of spleenocytes dose Similarly the significant increased SOD, GSH and reduced level of lipid peroxidation and decreased ESR, WBC's and lymphocytes were ob resorption were also reduced. The infiltration of leucocytes and loss of articular cartilage was significantly reduced in groups treated with the extracts. extracts of Indigofera tinctoria L showed the potent anti arthritis in rats.
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