There is experimental evidence of adverse effects of endosulfan on the male reproductive system, but there are no human data. Therefore, we undertook a study to examine the relationship between environmental endosulfan exposure and reproductive development in male children and adolescents. The study population was composed of 117 male schoolchildren (10-19 years of age) of a village situated at the foothills of cashew plantations, where endosulfan had been aerially sprayed for more than 20 years, and 90 comparable controls with no such exposure history. The study parameters included recording of clinical history, physical examination, sexual maturity rating (SMR) according to Tanner stages, and estimation of serum levels of testosterone, luteinizing hormone (LH), follicle-stimulating hormone, and endosulfan residues (70 study and 47 control subjects). Mean +/- SE serum endosulfan levels in the study group (7.47 +/- 1.19 ppb) were significantly higher (p < 0.001) than in controls (1.37 +/- 0.40 ppb). Multiple regression analysis showed that SMR scoring for development of pubic hair, testes, penis, and serum testosterone level was positively related to age and negatively related to aerial exposure to endosulfan (AEE; p < 0.01). Serum LH levels were significantly positively related to AEE after controlling for age (p < 0.01). The prevalence of congenital abnormalities related to testicular descent (congenital hydrocele, undescended testis, and congenital inguinal hernia) among study and controls subjects was 5.1% and 1.1%, respectively, but the differences were statistically nonsignificant. Our study results suggest that endosulfan exposure in male children may delay sexual maturity and interfere with sex hormone synthesis. Our study is limited by small sample size and nonparticipation.

India being a developing nation is faced with traditional public health problems like communicable diseases, malnutrition, poor environmental sanitation and inadequate medical care. However, globalization and rapid industrial growth in the last few years has resulted in emergence of occupational health related issues. Agriculture (cultivators i.e. land owners+ agriculture labourers) is the main occupation in India giving employment to about 58% of the people. The major occupational diseases/morbidity of concern in India are silicosis, musculo-skeletal injuries, coal workers' pneumoconiosis, chronic obstructive lung diseases, asbestosis, byssinosis, pesticide poisoning and noise induced hearing loss. There are many agencies like National Institute of Occupational Health, Industrial Toxicology Research Centre, Central Labour Institute, etc. are working on researchable issues like Asbestos and asbestos related diseases, Pesticide poisoning, Silica related diseases other than silicosis and Musculoskeletal disorders. Still much more is to be done for improving the occupational health research. The measures such as creation of advanced research facilities, human resources development, creation of environmental and occupational health cells and development of database and information system should be taken.

The association of fuel use and ocular morbidity in a village in western India was investigated in a cross sectional prevalence survey involving 469 randomly selected subjects. All subjects were interviewed and underwent medical and ophthalmological examination. Wood use was found to be an important factor in the aetiology of age dependent cataract (OR 2.12, 95% CI 1.03–4.34). When comparing wood only and LPG only users, the odds ratio was 3.47 (95% CI 1.05–11.50). In cases of eye irritation, coal use (OR 2.04, 95% CI 1.13–3.68) and cattle dung use (OR 1.83, 95% CI 1.35–2.47) were shown to be important factors, while male sex posed a lesser risk.

Background: In the backdrop of conflicting reports (some studies reported adverse outcomes of biomass fuel use whereas few studies reported absence of any association between adverse health effect and fuel use, may be due to presence of large number of confounding variables) on the respiratory health effects of biomass fuel use, this cross sectional survey was undertaken to understand the role of fuel use on pulmonary function.

This study was undertaken to investigate cases of respiratory morbidity seen at SNM hospital, Leh, who did not respond to routine treatment and whose radiological picture resembled pneumoconiosis. There are no mines or industries in any part of Ladakh and therefore exposure to dust from these sources is ruled out. Two factors considered responsible for the development of this respiratory morbidity were: (1) Exposure to dust from "dust storms." In spring dust storms occur in most parts of Ladakh. During these storms the affected villages are covered by a thick blanket of fine dust, and inhabitants are exposed to considerable amounts of the dust for several days. The frequency, duration, and severity of these dust storms vary considerably from one village to another. (2) Exposure to soot. The fuels used for heating and cooking consist of wood from a local bush called "malchung" and the dung of yaks, cows, horses, donkeys, and their interbreeds. Due to severe cold, the ventilation in the houses is usually kept at a minimum. The same fireplace is used for cooking and heating purposes. To conserve fuel during non-cooking periods, the wood is not allowed to burn quickly but is kept smouldering to prolong its slow heating effect. The dwellers are thus exposed to high concentrations of soot.Materials and methods Three villages, Saboo (A), Shey (B), and Chushot (C), situated near Leh town, were selected for the study. The characteristics of these villages are as follows: dust storms are rare in village A, moderate in village B, and severe in village C. Chimneys have been used for over 20 years in all houses in village A, for 10-20 years in most houses in village B, and in few houses and only recently in village C.The total populations of villages A, B, and C were 1045, 1136, and 924 respectively. As most of the cases of pneumoconiosis seen in the hospital were older than 50, only those subjects older than 30 were included in this study. Initially, a list of all villagers older than 30 was prepared and from this list 150 subjects from each village were selected for the study. The list showed that in village A and village B there were more women than men, whereas in village C this 825

This study was conducted to examine the relationship between the concentration of zinc and neutral alpha-glucosidase (NAG) with semen quality. Semen samples from 75 male partners of couples who were attending the Obstetrics and Gynecology Department were analyzed for semen quality. Based on sperm count, the subjects were divided into three groups. Zinc and neutral alpha-glucosidase activity were estimated in seminal plasma. Results showed that mean the alpha-glucosidase activity was lowest among the azoospermic group with respect to oligozoospermic and normozoospermic groups. Mean zinc levels were also lower among azoospermics compared to oligozoospermic and normospermic groups. The difference was statistically significant (p < 0.05). A significant positive correlation was observed between zinc levels and sperm count (r = 0.29, p < 0.05) and zinc and alpha-glucosidase activity (r = 0.31, p < 0.05) in seminal plasma. These results suggest that zinc and neutral alpha-glucosidase seem to play an important role in human reproduction.

The prevalence of GTS among non-FCV tobacco workers is high. However, from viewpoint of severity it can be considered as mild acute nicotine toxicity, which is relieved without medication. No significant difference is observed as regards to chronic health effects among tobacco workers and control workers.

An occupational injury surveillance study (record study of five years duration) was conducted involving the workers of a fertilizer producing industry in eastern India to assess whether the risk of occupational accidents in temporary piece rated workers was higher in comparison to the permanent time rated workers. At the same time, to collect the personal details of the workers who have worked in the industry in the study period, an interview was also conducted. Mean age of temporary piece rated workers and permanent time rated workers were (35.9 ± 12.5) and (35.3 ± 11.4) respectively. Distribution of other variables like nature of work, level of education, experience, habits were also very similar between the two worker groups. Accident incidence rate, accident frequency rate and accident severity rate were found to be significantly higher in temporary piece rated workers. This difference was more prominent in case of time-loss accidents than in no timeloss accidents. Relative risk has varied from 2.3 to 18.0 in case of time-loss accidents. In case of no time-loss accidents, it has varied from 1.1 to 2.6. When relative risk is considered after taking both types of accidents together, it has ranged from 1.2 to 3.5. This study concluded that the temporary piece rated workers are more vulnerable to occupational accidents.