DEET (N,N-Diethyltoluamide) was applied dermally t o groups o f 80 Sprague Dawley r a t s 5 days/week f o r 9 weeks (63 days), a t three dose levels, (100, 300, and 1000 mg/kg). The undiluted material was applied w i t h micropipettes t o shaved patches. and the material w e t out onto the skin. Dose levels were calculated based on mean weights and adjusted weekly by reweighing h a l f the animals i n each group and calculating a mean body weight. were scheduled f o r k i l l a t three times; days 36-37, 65-66 and 95-96 a f t e r i n i t i a t i o n o f treatment. Data collected a t each k i l l included sperm count, v i a b i l i t y as assessed by ATP levels and morphology; testes histopathology (control and high-dose groups only) and body and organ weights ( l i v e r , kidneys and testes). DEET, when applied dermally, d i d not a l t e r sperm count, sperm morphology, sperm v i a b i l i t y , body weight o r food consumption a t any dose level tested.
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