This study investigated the effects of dietary niacin on growth performance, feed utilization and non-specific immune response in juvenile Pacific white shrimp. Six isonitrogenous and isolipidic practical diets were formulated with graded niacin levels of 10. 9, 65.8, 121.2, 203.4, 387.5 and 769.3 mg kg À1 of dry diet, respectively. Results indicated that per cent weight gain (WG), specific growth rate (SGR), feed efficiency (FE), protein efficiency ratio (PER) and protein productive value (PPV) were significantly influenced by the dietary niacin levels. The maximum WG and SGR occurred at 121.2 mg kg À1 niacin diet. However, survival and proximate composition of whole body were not significantly affected by the dietary niacin levels. Dietary niacin levels had no significant effects on the total protein, glucose, triacylglycerol and cholesterol contents in the haemolymph. The activity of catalase and lysozyme in the haemolymph was significantly affected by dietary niacin levels. Based on a two-slope regression analysis of SGR against dietary niacin level, the dietary niacin requirement of juvenile Pacific white shrimp was 109.6 mg kg À1 .

LAA triggers G2 /M phase cell cycle arrest via up-regulating p21expression as well as down-regulating cdk-1cyclinA singling pathway, and induces apoptotic cell death through inhibiting PI3K-Akt survival pathway in human lung adenocarcinoma A549 cells. While LAA has no significant cytotoxic effect toward normal human embryonic lung fibroblast HELF cells, and moreover, LAA could amplify the antineoplastic effects of cisplatin toward A549 cells. Lastly LAA also bears anti-cancer and apoptosis-inducing effects in vivo, and it could decrease the volume and weight of subcutaneous tumor mass obviously as well as expand lifespan of mice. These findings may provide a new perspective for elucidating the complicated molecular mechanisms of LAA-induced cancer cell growth-inhibition and death, providing a new opportunity of LAA as a potential candidate anti-neoplastic drug for future cancer therapeutics.