Nitrophenolic and alkyl phosphate metabolites of methyl and ethyl parathion in the urine of human subjects soon after doses of 1 to 4 mg have been ingested. Particular alkyl phosphates can serve as specific indices of absorption of the respective parathions. Paranitrophenol and diethyl thiophosphate are rapidly eliminated in the urine, while excretions of dimethyl phosphate, and particularly diethyl phosphate, are more protracted. Cumulative excretions of paranitrophenol and alkyl phosphates exhibit sufficient dose-dependence at convenient intervals following parathion ingestion to encourage use of metabolite measurements in estimating occupational absorption of the parathion insecticides.

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An orderly examination of the laboratory parameters involved in the recovery of the chlorinated hydrocarbon residue, p,p′-DDE, from human blood serum by the method of Dale, Curley, and Cueto is reported. The age of the serum, amount of hexane used for extraction, duration of mixing time, and temperature were varied; the results were examined statistically to discern the possible effects. All these factors had a statistically significant effect upon the results of the analytical quantitation performed by GLC. The aging time of these rum and the amount of hexane used for the extraction as well as the aging time and duration of mixing time were intercorrelated. Modification for use of the published procedures based upon these findings is suggested.

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