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Images Figs. 7-10 Figs. 12-17 Fig. 3 Fig. 4 Fig. 5 Fig. 6

In the previous communication (Zamenhof et al., 1953) the study of the inactivation of the transforming principle (deoxyribonucleic acid [DNA] having transforming activity) by several physical and chemical agents has been reported. Some of those agents, especially Fe-++, are known to be potent mutagens; others such as temperature oscillation are reported to be weak mutagens, but they have not been tested on the living cell under drastic conditions, such as heating above 76 C, available for the study of the transforming principle in vitro. Mutagenic action by other

The adrenal glands from twenty-four cases of sudden death during pregnancy and immediately post partum have been examined. The mean combined adrenal weight in the pregnancy cases was slightly greater than in controls, but the difference was not statistically significant. There was, however, a significant increase in the width of the z. fasciculata in the pregnancy cases due toan increase in the width of the inner partof this zone. This change occurred early in pregnancy, and there was no progressive increase in width with the duration of the pregnancy. Histochemical tests showed that the only difference from the controls was in the inner part of the z. fasciculata where there was reduction in the amount of sudanophilia. The appearance of the cortex in pregnancy was quite unlike that found in glands stimulated by systemic disease or corticotrophin. These findings are discussed in relation to the chemical evidence of increased urinary steroid excretion in pregnancy.It is frequently stated that the human adrenal gland hypertrophies during pregnancy, and it would seem that this fact is so well established that little or no reference to

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