An open, multi-centre study was carried out in 117 pregnant women presenting with vaginal candidosis to assess the effectiveness of econazole in providing mycological control and symptom relief, and in preventing, as far as possible, the risk of contamination of the newborn: nearly 50% of the patients were in the last month of pregnancy. Patients received a single course of econazole given as 1 vaginal pessary (150 mg) on 3 consecutive days. Clinical and mycological assessments were made 1 week after the end of treatment and again at delivery, unless it happened before the first control visit. The infants were investigated at birth and 1 week afterwards. An 80% mycological cure rate was obtained and there was complete or marked relief of symptoms in the majority of patients after treatment. Twenty patients received further antimycotic treatment before delivery either because of failure (13) or relapse (7) after the single course of econazole. The relapse rate was 13.3%. No congenital abnormality was observed in the neonates and only 1 infant, born to a mother who was positive for Candida at the time of delivery, developed oral candidosis. Local tolerance of the vaginal pessaries was good and there were no reports of side-effects.
The rate of glycoprotein synthesis by the columnar cells of the human endocervix was measured during one cycle in 12 women by autoradiography. An increase in the rate of synthesis was associated with an increase in the plasma oestradiol concentration. A change in progesterone concentration in the blood did not seem to influence cervical glycoprotein synthesis. The ratio between the different cell types in the epithelium, basal cells, ciliated cells and mucus cells did not show cyclic variation in the cycles studied.
Scrapings of endometrium\and uterine contents of 10 women were analysed. In the uterine lumina of two women that used synthetic progestagens, a considerable amount of mucus was present. We fractionated the mucus by CsCl density equilibrium centrifugation into glycoprotein and protein fractions. With sugar and amino acid analysis the glycoprotein could be classified as a typical epithelial glycoprotein, resembling the cervical glycoprotein. It contains neuraminic acid (6.2%) and sulfate (8.4%). From the uteri of the other 8 women, who did not use hormones, a small amount of a similar glycoprotein could be isolated.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.