Efficacy of econazole (‘Gyno-Pevaryl’ 150) in vaginal candidosis during pregnancy

Goormans, E.; Beek, Josine; Declercq, J.; Loendersloot, E W; Roelofs, H. J. M.; Zanten, A. van

doi:10.1185/03007998509109606

Cited by 3 publications

(2 citation statements)

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“…In another study, 117 pregnant women with a mean gestation age of 30 weeks were treated with a 3‐day regimen of vaginal econazole. Authors reported no congenital anomalies, although three stillbirths and one in utero death were reported . In 2002, Kragie et al .…”

Section: Antifungalmentioning

confidence: 99%

“…Authors reported no congenital anomalies, although three stillbirths and one in utero death were reported. 53 In 2002, Kragie et al 54 studied azole antifungals for their potential to inhibit aromatase enzyme and contribute to adverse events in human and animal pregnancies. They reported the most potent inhibitor to be econazole, and the least potent to be miconazole.…”

Section: Clotrimazole (Category B)mentioning

confidence: 99%

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Topical antiviral and antifungal medications in pregnancy: a review of safety profiles

Patel

Schwartz

Lambert

2017

Acad Dermatol Venereol

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Medications should be employed with caution in women of childbearing age who are pregnant or considering pregnancy. Compared to oral or parenteral agents, topical medications have limited systemic absorption and are deemed safer. However, their safety profile must be assessed cautiously due to the limited available data. In this article, we aggregate human and animal studies to provide recommendations on utilizing topical antiviral and antifungal medications in pregnancy. For antiviral medications, acyclovir and trichloroacetic acid are safe to use in pregnancy. Docosanol, imiquimod and penciclovir are likely safe, but should be utilized as second-line agents. Podofilox and podophyllin resin should be avoided. For antifungal medications, clotrimazole, miconazole and nystatin are considered first-line agents. Butenafine, ciclopirox, naftifine, oxiconazole and terbinafine may be utilized after the above agents. Econazole should be avoided during the first trimester and used sparingly during 2nd and 3rd trimester. Ketoconazole and selenium sulphide are likely safe, but should be employed in limited areas for brief periods.

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Section: Antifungalmentioning

confidence: 99%

Section: Clotrimazole (Category B)mentioning

confidence: 99%