Two case histories are presented to illustrate the clinical and pathological findings of a malignant catarrhal fever-like disease as seen in farmed red deer in New Zealand. Attention is drawn to the similarities with some exotic diseases and the suggestion is made that deer may act as a reservoir for the aetiological agent.
A series of trials was set up to investigate the acute and sub-acute oral toxicity of brodifacoum to the European rabbit (Oryctolagus cuniculus). The acute, oral LD so was 0.20 mg kg"! (95% confidence limits 0.15 -0.28 rng kg"), The 3-and 5-day sub-acute oral LD sOs were 0.22 rng kg-I (0.15 -0.31 mg kg-I) and 0.16 rng kg -I (0.12 -0.21 rng kg-I) respectively.
The oral toxicity of an anticoagulant, brodifacoum, was tested with dogs of mixed breed, age, and sex. In the first trial using 20 dogs, predominantly under 2 years old, an acute oral LDso of 1.09 rng kg-l (95% confidence limits, 0.49-2.42 rng kg-I) was derived. In the second trial with 59 mixed age dogs an acute oral LDso of 3.56 rng kg-I (2.13-6.03 rng kg-I) resulted. No significant differences as a result of age or sex were found.
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