The acute oral toxicity of the anticoagulant brodifacoum to dogs

Godfrey, M. E. R.; Reid, T. C.; McAllum, H.J.F.

doi:10.1080/03015521.1981.10427819

Cited by 7 publications

(2 citation statements)

References 6 publications

(7 reference statements)

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“…Reports in the U.S. of secondary poisoning to pets from SGARs do not figure in the veterinary literature (Murphy andGerken 1986, Corrigan 2001), yet dogs and cats represent a far more likely scenario in being exposed to poisoned commensal rodents than wildlife. The toxicity of SGARs to dogs has been variously reported, and the most robust study puts brodifacoum as comparable in toxicity (LD 50 of 3.56 mg/kg) to the other SGAR products with regard to canines (Godfrey et al 1981). Diphacinone, a FGA rodenticide which would not be restricted under the EPA's proposal, is as toxic to canines as some SGARs, and cats and dogs are highly susceptible to the effects of the acute rodenticide cholecalciferol, which at 750 ppm is from 15 to 30 times more concentrated than the SGARs (Corrigan 2001).…”

Section: Potential Hazards To Companion Animalsmentioning

confidence: 99%

Concerns Regarding Proposed Restrictions in the Use of Second-Generation Anticoagulant Rodenticides for Commensal Rodent Control

Kaukeinen¹,

Colvin²

2008

vertebrate_pest_conference

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The development of second-generation anticoagulant rodenticides for commensal rodent control arose from the need to overcome genetic resistance to earlier anticoagulants, to improve efficacy, and to reduce hazard over older acute rodenticide materials. Over the past three decades, the second-generation anticoagulant products have become the principal commensal rodenticides used in the U.S. and elsewhere. During this long usage, individual cases of human and nontarget wildlife exposure have been documented, and the significance has been debated. Following a lengthy re-registration and review process, the U.S. Environmental Protection Agency in January 2007 proposed restrictions on the use of second-generation anticoagulant rodenticides for commensal rodent control. The proposed restrictions would shift emphasis to other rodenticides, including those with inherent problems that were the basis for developing second-generation anticoagulants. Reduced efficacy, prolonged public exposure to rodents, limitations in bait formulations and placements, increased genetic resistance, and greater application rates (exposure) are anticipated if these restrictions are adopted. Various nontarget concerns will remain with alternative products and use patterns by professional users and consumers, including use of products without specific antidotes. These impacts would occur amidst increasing rodent problems in many U.S. municipalities with declining management resources and aging infrastructure. Alternative measures should include use of human taste deterrents in baits and revised label statements to limit the use of all commensal rodenticide from sensitive areas, including placement along fence lines, and bordering natural habitats.

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Section: Potential Hazards To Companion Animalsmentioning

confidence: 99%

Concerns Regarding Proposed Restrictions in the Use of Second-Generation Anticoagulant Rodenticides for Commensal Rodent Control

Kaukeinen¹,

Colvin²

2008

vertebrate_pest_conference

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“…However, because phosphorus is an inhumane poison, the halogenated anticoagulant brodifacoum has been proposed as an alternative (Godfrey & Lyman 1980). Previous trials (Godfrey & Lyman 1980 Godfrey et al 1981a) have shown the effectiveness of brodifacoum against rabbits. Other trials have shown that brodifacoum poses less danger to dogs (Godfrey et al 1981b), and no greater danger to birds, than compound 1080 (Godfrey unpublished data).…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity of brodifacoum to sheep

Godfrey¹,

Laas²,

Rammell³

1985

New Zealand Journal of Experimental Agriculture

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The acute oral toxicity of brodifacoum to sheep was examined in a trial using 40 sheep. Mortalities of 0, 12.5, 37.5, 50, and 25% resulted from doses of 1.56, 3.13, 6.25, 12.5, and 25.0 mg kg-I respectively. The low mortality at 25 mg kg-I was attributed to precipitation of insoluble brodifacoum in the sheep's alimentary canal. An LD sD of 11 mg kg-lor lower, derived from dosing at 1.56-12.5 mg kg-I, is considered a better estimate than the previously reported minimum of 25 rng kg-I.

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A Field Assessment of the Anticoagulant Brodifacoum Against Rabbits, Oryctolagus-Cuniculus

Crosbie¹,

Laas²,

Godfrey³

et al. 1986

Wildl. Res.

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The effectiveness of 100 p.p.m. brodifacoum for controlling an island population of rabbits was assessed and compared with that of 200 p.p.m. 1080 (sodium monofluoroacetate). Both compounds were applied in an apple-based, raspberry-flavoured jam bait after pre-feeding with the same non-toxic bait. Brodifacoum and 1080 both reduced rabbit populations by 85% on average, compared with an average 'natural' decline of 34% on untreated sites; these estimates of poisoning mortality may be considered conservative, however, because of post-poisoning migration onto poisoned sites.

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The acute oral toxicity of the anticoagulant brodifacoum to dogs

Cited by 7 publications

References 6 publications

Concerns Regarding Proposed Restrictions in the Use of Second-Generation Anticoagulant Rodenticides for Commensal Rodent Control

Concerns Regarding Proposed Restrictions in the Use of Second-Generation Anticoagulant Rodenticides for Commensal Rodent Control

Acute toxicity of brodifacoum to sheep

A Field Assessment of the Anticoagulant Brodifacoum Against Rabbits, Oryctolagus-Cuniculus

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