Two successful pregnancies (singleton followed by twins) following ovum donation/in-vitro fertilization in a 46,XY woman have been studied. Although similar cases have previously been presented: in a pure XY patient and in a 45,X/46,XY patient, this case is one in which a subsequent successful pregnancy has resulted. In such patients, the rate of Caesarean section appears to be increased, and we postulate that the hypoplastic nature of the uterus, although able to respond quite well to both exogenous and endogenous hormones to accept and maintain a pregnancy, may lack the capability to respond fully in labour by dilating appropriately.
This is a questionnaire based study of 501 women enquiring about anonymous oocyte donation at a private in-vitro fertilization (IVF) unit, investigating the demographic characteristics and logistic issues involved in ovum donation. The 501 women were made up of 356 women who did not donate ('non-donors') and 145 women who eventually donated their oocytes ('donors'). Although there was a majority of housewives among the enquirers, women in full-time employment were the majority of actual donors. Logistic factors such as the travel and time commitment involved were major reasons for non-donation as well as concerns about complications. There was a paucity of ethnic donors. Recruitment strategies must focus on retaining potential donors and ensuring a higher proportion become actual donors. These strategies must address the logistic difficulties associated with non-donation including transport problems and social commitments by assisting with childcare provision and travel. Improving donor education and the access to more personal and non-threatening information were other areas that needed attention which were highlighted in the survey.
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