Summary. Cardiac arrhythmias during hip-joint replacement are caused by monomers of methyl methacrylate from the bone cement. Both the amount of MMA monomer that is released into the bloodstream and the fall in blood pressure are dependent on the extracorporeal polymerization time (mixing time). Although prolongation of the mixing time reduces the frequency of intraoperative hypotension, it has no effect on intraoperative fat embolism. The temporal course and extent of effect of MMA monomer. In 3000 cases, implantation was effected with no monomer-induced lethal complications.
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