2-Thiouracil-5-sulfonylchloride 1 reacted with a series of aromatic and heterocyclic amines to give 2a-j. The same compound 1 was reacted with a series of sulphonamides giving different sulphonamides of type 3a-e. On the other hand compound 1 was allowed to react with p-aminoacetophenone givining compound 4 which in turn was allowed to react with derivatives of alkyl thiosemicarbazides to give thiosemicarbazones of type 5a-e, also compound 4 was monobrominated to give compound 6 which in turn was reacted thiosemicarbazones of some aldehydes to give the corresponding thiazole derivatives 7a-f. In the same time compound 4 was reacted with a series of aromatic and heterocyclic aldehydes givining chalcones 8a-g (Claisen-Schemidt reaction). Also compound 4 was allowed to react with a series of aromatic and heterocyclic aldehydes, ethyl cyano acetate and/or malononitrile, and ammonium acetate giving pyridine derivatives 9a-d and 10a-e respectively. The biological effects of some of the new synthesized compounds was also investigated.
Pyrimidine derivatives R 0510 Synthesis and Biological Evaluation of New Pyrimidine Derivatives. -Some of the new pyrimidine derivatives (III), (V) and (VIII) show cytotoxic and/or antimicrobial activity. -(FATHALLA*, O. A.; RADWAN, H. H.; AWAD, S. M.; MOHAMED, M. S.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 45 (2006) 4, 980-985; Dep. Med. Chem., Natl. Res. Cent., Dokki, Cairo, Egypt; Eng.) -M. Kowall 33-166
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