Pendant quatre semaines de traitement et une semaine sans traitement, des évaluations in vivo des marqueurs sériques du coeur de lapin, traités par un extrait aqueux de Phyllanthus amarus, ont permis de déterminer l'activité enzymatique sérique de la glutamo-oxaloacétique transaminases (GOT), la lactate déshydrogénase (LDH) et la créatine phosphokinase (CPK). Les lapins traités par voie intrapéritonéale avec différentes doses variant de 0 à 100 mg/kg de poids corporel ont permis d'avoir, par rapport aux valeurs normales, les résultats des CPK et LDH qui montrent respectivement des réductions de 40 et de 60 %, alors que la GOT, à la troisième semaine de traitement, augmente de quatre fois sa valeur normale. En conclusion, les extraits totaux aqueux de Phyllanthus amarus auraient un effet cardioprotecteur.
Mots clés : Phyllanthus amarus -Coeur -GOT -LDH -CPK
Assessment of the enzymatic serum markers of the heart of rabbits treated by Phyllanthus amarus (Euphorbiaceae)Abstract: Within a four-week treatment and a week without treatment, a serumal enzyme activity relating to GlutaoOxaloacetic Transaminase (GOT) including Lactate Deshydrogenase (LDH) and Creatine Phosphokinase (CPK) was determined through in vivo evaluations of serum markers of the hearts of rabbits that were under Phyllanthus amarus aqueous extract based treatment. Doses ranging from 0 to 100 mg/kg/body weight were administered to the rabbits by intraperitoneal route, which, in relation to normal values, resulted in 40 and 60% reduction in CPK and LDH respectively, whereas in the third week of treatment there was a three-fold increase in GOT compared with its normal value. To conclude, Phyllanthus amarus aqueous extracts seem to generate cardioprotective activity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.