In a series of experiments a new 5% solution of oxytetracycline (Vendarcin®) was compared with Rolitetracycline 5% and/or 2.5% without a local anesthetic when injected in animals by several topical and systemic routes of administration. These routes were: subcutaneous, intramuscular, intravenous, intra-arterial, intra-articular, intraperitoneal, intrapleural, intrathecal and subconjunctival. The primary aim of the investigation was to find out how the Vendarcin solution compared with Rolitetracycline solution in producing irritant effects at the site of injection. To try to provoke local effects in some cases rather high doses were used. This occasionally resulted in severe systemic effects. If indicated, liver and kidneys were macroscopically and microscopically examined. The findings will be discussed immediately following the description of the results of each route of administration employed. Our experiments lead to the conclusion that, in general, animal tissues tolerate 5% Vendarcin at the site of injection much better than they do 5% and/or 2.5% Rolitetracycline. Moreover, there are clear indications that the systemic toxicity of Vendarcin is also less.
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