The occurrence of iron and ceroid in coronary arteries

Schornagel, H. E.

doi:10.1002/path.1700720133

Cited by 24 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The amount of ceroid in aortic lesions increases with the degree of intimal thickening (43, 44); it is present in higher concentrations in both fibrous and complicated plaques than in lipid plaques or in normal areas (44). In a study of coronary arteries (45), ceroid was found earlier in life in men than in women, and it was present in the coronary arteries of nearly all subjects who had died from cardiac infarction.…”

Section: Relationship To Diseasementioning

confidence: 99%

Prolongation of Life: Role of Free Radical Reactions in Aging

Harman

1969

J American Geriatrics Society

132

View full text Add to dashboard Cite

The mean life span has plateaued in the developed countries at around 70 years. Future substantial increases in the mean life span are apt to be due to inhibition of the process(es) involved in aging. One potentially practical means of inhibiting the rate of human aging is based on the hypothesis that free radical reactions play a significant role in the degradation of biological systems. Experiments based on this hypothesis have been encouraging. For example, several inhibitors of free radical reactions have been found to increase the mean life span of mice when added to the daily diet; 2‐mercaptoethylamine and butylated hydroxytoluene were the most effective. Likewise, decreasing the amount and degree of unsaturation of the dietary fat of female C3H mice resulted in a decrease in the mortality rate. The probable role of free radical reactions in the pathogenesis of four age‐associated diseases—cancer, atherosclerosis, hypertension and amyloidosis—is discussed. It is suggested that the addition of one or more inhibitors of free radical reactions to nutritionally adequate and acceptable natural diets selected to minimize the intake of substances that might participate in random endogenous free radical reactions, may increase the average life span of man by five or more years, with accompanying increases in the years of useful, healthy life.

show abstract

Section: Relationship To Diseasementioning

confidence: 99%

Prolongation of Life: Role of Free Radical Reactions in Aging

Harman

1969

J American Geriatrics Society

132

View full text Add to dashboard Cite

show abstract

“…Whether fatty acid peroxides are formed in animal tissues in vivo has been a controversial question for some years (1)(2)(3)(4)(5)(6). Substances which presumably are derived from peroxides or their degradation products have been detected in tissue extracts (7)(8)(9)(10), but it is difficult to prove their existence in the live organism. It seems apparent that only minute concentrations of peroxides, if any, occur in vivo, and in the absence of information on their turnover rate, it is impossible to draw conclusions as to the amounts formed.…”

Section: Introductionmentioning

confidence: 99%

Metabolism of 1‐¹⁴C‐methyl linoleate hydroperoxide in the rabbit

Findlay

Draper

Bergan

1970

Lipids

View full text Add to dashboard Cite

The metabolism of 1‐14C‐methyl linoleate hydroperoxide (1‐14C‐MLHP) by the rabbit was investigated. Administration of 1.1–1.9 mg of 1‐14C‐MLHP by ear vein injection proved lethal to four of the nine experimental animals. After 2 hr the lungs and liver contained 3.3% and 7.2%, respectively, of the dose. This radioactivity was found to be associated primarily with intact 1‐14C‐MLHP. The triglycerides from these tissues also contained14C‐trienoic and14C‐dienoic fatty acids. Of the dose, 68% was recovered as14CO2 in 2 hr compared to 39% after 1‐14C‐methyl linoleate injection. The triglycerides from kidney adipose tissue contained a small amount of14C‐hydroxy fatty acid, providing confirmation of previous evidence for the presence of a fatty acid hydroperoxide reductase in animal tissues.

show abstract

“…Hartroft (1953) found lipid pigment granules in atheromatous plaques which resulted from the interaction between the deposited lipid and extravasated erythrocytes. Schornagel (1956) found iron blood pigments and lipid pigment granules often together in human coronary arteries.…”

Section: Discussionmentioning

confidence: 95%

Lipopigment in odontogenic cysts

Buchner

David

1978

J Oral Pathology Medicine

View full text Add to dashboard Cite

A study of 105 odontogenic cysts revealed the presence of pigmented cells in the cyst wall in 38% of the cases. The frequency of pigmented cells was higher in the inflammatory odontogenic cysts than in the developmental cysts. Although isolated pigmented cells were seen within the epithelial lining and cyst cavity, the larger collections were closely associated with cholesterol crystals and hemosiderin deposits; they contained light brown cytoplasmie pigment which manifested sudanophilia, acid-fastness, silver reduction capacity, PAS positivity and yellow autofluorescence in ultraviolet light. The morphology, histochemical reactions and autofluorescence suggest that the pigmented cells are macrophages containing ceroids.It has been suggested that the hemosiderin which is found in the cyst wall serves as an oxidation catalyst for the locally hberated lipids, the end result of which is the formation of the ceroid pigment.

show abstract

The occurrence of iron and ceroid in coronary arteries

Cited by 24 publications

References 7 publications

Prolongation of Life: Role of Free Radical Reactions in Aging

Prolongation of Life: Role of Free Radical Reactions in Aging

Metabolism of 1‐¹⁴C‐methyl linoleate hydroperoxide in the rabbit

Lipopigment in odontogenic cysts

Contact Info

Product

Resources

About

The occurrence of iron and ceroid in coronary arteries

Cited by 24 publications

References 7 publications

Prolongation of Life: Role of Free Radical Reactions in Aging

Prolongation of Life: Role of Free Radical Reactions in Aging

Metabolism of 1‐14C‐methyl linoleate hydroperoxide in the rabbit

Lipopigment in odontogenic cysts

Contact Info

Product

Resources

About

Metabolism of 1‐¹⁴C‐methyl linoleate hydroperoxide in the rabbit