Objectives:Depression is a mental disorder, affecting the quality of life. Our study explores the efficacy of Pranic Healing (PH), as an adjuvant therapy in treating depressionMethods:In this randomised double-blind controlled trial, 52 participants with a mean age of 34.4 years, with mild to moderate depression were assessed using the Hamilton Depression Rating (HAM-D) scale during the 5-week study. Both Medication + PH (MedPH) and Medication + Mock PH (MedMockPH) groups comprising 26 members received Pranic and mock healing lasting 20 minutes per session respectively once a week for 4 weeks, along with the antidepressant drug.Results:The average decrease in HAM-D score in MedPH was median 11 (Interquartile Range (IQR) 7–12) and was significantly higher compared with the MedMockPH group median 6.5 (IQR 3–9). At pre-assessment, both groups had 8 cases of mild and 18 cases of moderate depression. At post-assessment, HAM-D showed that the improvement in depression category was seen in 69.2% of participants in the MedMockPH group and 100% in MedPH group.Conclusions:These results give first the evidence that PH can aid as an adjuvant therapy for depressed people.
Metaplastic carcinomas of the breast are malignant breast neoplasms composed of a mixture of both epithelial and mesenchymal elements. The rarity of this tumor is exemplified by the fact that it accounts for only about 0.2% of all breast carcinomas. It can present histologically with diverse differentiation and the exact histogenesis of these tumors is unknown. The present case is reported for its rarity and for the presence of transitional cell differentiation along with the other usual components of metaplastic carcinoma. Transitional cell differentiation in a metaplastic carcinoma has not been documented in the literature. Besides this, it highlights the importance of special stains and immunohistochemistry in evaluating these carcinomas and the need for early diagnosis and excision of these tumors as these carcinomas generally have a poorer prognosis as compared to breast carcinomas without metaplasia, with the tumor size having an important bearing on the outcome of this condition.
Hidrocystomas are rare cystic lesions that form benign tumours of the sweat glands. In this report, a clinical case of multiple apocrine hidrocystomas on both the upper and lower eyelids, and on both the malar regions has been discussed. These lesions are less likely than the eccrine lesions to occur at the periorbital region.Vani D, DayananDa T R, ShaShiDhaR h B, BhaRaThi M, haReeSh R S KuMaR, V RaViKuMaR InTRoduCTIonHidrocystomas are rare, benign, cystic lesions of the skin -they can be either eccrine or apocrine and are often found on the head, neck and the trunk regions [1]. These tumours have also been reported to occur on the penis, axillae, and in the anal region [2].Apocrine hidrocystomas are often regarded as adenomas, because the secretory cells are not flattened and they have papillary projections which extend into the lumen [3]. They are usually solitary and are found mostly on the head and neck and along the eyelid margins, near the inner canthus. The apocrine lesions are less likely than the eccrine lesions to occur at the periorbital regions [4].This case report deals with such a rare tumour which presented as multiple cystic lesions on both the upper and the lower eyelids and on both the malar areas. CASe RepoRTA 75 year old male patient presented with multiple, small, translucent, cystic papules which were filled with a watery fluid, which had been present since five years and he was asymptomatic. On local examination, the lesions were observed on both the upper and lower eyelids and on both the malar areas. The largest cyst measured 2x2cms [Table/ Fig-1]. A clinical diagnosis of hidrocystoma was offered. The patient underwent, under local anaesthesia, an excisional biopsy of the mass and the specimen was subjected to a histopathological examination.Pathological Findings: The gross examination of this specimen showed a grey white cyst which measured 1.5x1cms. The histopathologic examination of the paraffin sections which were stained with haematoxylin-eosin, revealed the presence of a cyst in the dermis, which was lined by an inner layer of a secretory columnar epithelium, which lay above an outer myoepithelial cell layer. At places, the secretory epithelium showed decapitation [Table/ Fig-2], which suggested an apocrine hidrocystoma. dISCuSSIonThe skin adnexal neoplasms exhibit a morphological differentiation towards one or more types of adnexal structures which are found in the normal skin (the pilosebaceous units, eccrine glands, and the apocrine glands) and they comprise a wide spectrum of benign and malignant tumours [5]. The apocrine glands are most frequently present in the axillae, the groin, the external auditory canal, the eyelids and on the nipple. The apocrine hidrocystomas are benign adenomatous cystic proliferations which are derived from the apocrine sweat glands, which often occur as solitary translucent cystic lesions, most commonly on the head and neck, especially in the periocular tissues [3].The exact stimulus for the development of an apocrine hidrocystoma is unknown...
Background: Eyelid lesions are encountered by all primary care physicians and Ophthalmologists. Histology of eyelid comprises various components and structures that give rise to a wide spectrum of pathologies. The clinical presentation of eyelid lesions is myriad with benign lesions masquerading malignant tumours. Though eyelid lesions are fairly common in Indian subcontinent, there is paucity of reports in Indian literature. This study was undertaken to characterize the distribution of various eyelid lesions and clinicopathological correlation in a tertiary care centre of South India. Objectives: To retrospectively carry out a clinicopathological analysis of eyelid lesions requiring surgical excision in the Department of Pathology of a tertiary care centre in South India. Methods: A retrospective review of clinicopathological profile of excised eyelid lesions diagnosed in our tertiary care centre was done. Clinicopathological data were retrieved from patient's clinical records and biopsy reports. Result: Among 219 eyelid lesions, 192 were benign lesions and 27 were malignant tumours. The most common eyelid lesion was dermoid cyst (69 cases) followed by Nevus (32 cases) and Pyogenic Granuloma (12 cases). The most common malignant eyelid lesion was Sebaceous Cell Carcinoma (13 cases). Conclusion: Dermoid cyst and Nevus are the most common eyelid lesions requiring biopsy and sebaceous cell carcinoma is the most common malignant eyelid tumour. All surgically excised eyelid lesions must be subjected to histopathological examination without fail to provide a definitive diagnosis, continued patient care and management.
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