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Vascular lesions of the labyrinth have been under investigation in this laboratory for the past four years. The effect of obstruction of the inferior cochlear vein was reported on in 1952. 1 Only minimal histological change and no functional change as tested electrically was found. Further studies have been made possible by development of a method for direct observation of the vessels in the stria vascularis and spiral ligament through the microscope and recording by means of the motion picture camera.A series of direct observations on the circulation following this procedure in the living guinea pig have been recently described by US. 2•3As stated in one of these reports the effect of interruption of the inferior cochlear vein has been found to depend upon the location of the obstruction with relation to collateral vessels. Obstruction of the vein along with its collaterals has been found to produce an immediate reduction of blood flow in the strial capillaries. Preliminary functional tests (microphonic and action potentials) indicate a profound loss of auditory function.In order to determine the histopathologic changes produced by interruption of the venous return in this manner a series of acute and chronic experiments have been carried out.