XXVII Extensive Venous Obstruction of the Labyrinth

Abstract

Vascular lesions of the labyrinth have been under investigation in this laboratory for the past four years. The effect of obstruction of the inferior cochlear vein was reported on in 1952. 1 Only minimal histological change and no functional change as tested electrically was found. Further studies have been made possible by development of a method for direct observation of the vessels in the stria vascularis and spiral ligament through the microscope and recording by means of the motion picture camera.A series of direct observations on the circulation following this procedure in the living guinea pig have been recently described by US. 2•3As stated in one of these reports the effect of interruption of the inferior cochlear vein has been found to depend upon the location of the obstruction with relation to collateral vessels. Obstruction of the vein along with its collaterals has been found to produce an immediate reduction of blood flow in the strial capillaries. Preliminary functional tests (microphonic and action potentials) indicate a profound loss of auditory function.In order to determine the histopathologic changes produced by interruption of the venous return in this manner a series of acute and chronic experiments have been carried out.

Photochemically induced focal cochlear lesions in the guinea pig: II. A transmission electron microscope study

“…The sequence of cellular damage observed in the present study is different from that produced by the obstruction of the anterior inferior cerebellar artery (Kimura and Perlman, 1958), or the inferior cochlear vein and its collaterals (Kimura and Perlman, 1956). In these cases of whole inner ear ischemia, the stria was reported to detach from the spiral ligament close to the spiral prominence within 1 hour.…”

Ototoxic Effect of Quaternary Ammonium Compounds

“…Berg (1951) observed that the otolithic membranes had disappeared in cats treated with streptomycin. Kimura & Perlman (1956) observed the same phenomenon after venous obstruction of the labyrinth. Recently I have observed the loss of otolithic membranes in guinea pigs after middle ear exposure to the disinfectant chlorhexidine (Aursnes, 1980 b).…”

Postmortem Changes in the Vestibular and Cochlear Receptors (Guinea Pig)

“…3,4 In Figure 1, midmodiolar section of guinea pig and cat temporal bones are illustrated. 3,4 In Figure 1, midmodiolar section of guinea pig and cat temporal bones are illustrated.…”