A series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j has been prepared by the condensation of different substituted chalone derivatives 1 with p-toluidine 2. The synthesized compounds were screened for their antibacterial activity againstStaphylococcus aureusandEscherichia coli.
ChemInform Abstract The title compounds (II), (III), and (IV), synthesized by oxidative alkaline or acidic ring closure reaction of the hydroxychalcones (I) are screened for their antibacterial and antifungal activity against Staph. aureus, Esch. coli and Asperg. niger. They have only moderate activity.
179ChemInform Abstract Condensation reaction of the chalcones (I) with phenylhydrazine (II) or hydroxylamine (IV) yields the pyrazolines (III) and the isoxazolines (V) respectively.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.