ChemInform Abstract: Studies on Flavonoids. Preparation and Antimicrobial Activity of 7‐(n‐Butoxy)‐6‐nitro/H‐flavones/flavonols/flavanones.

Abstract

ChemInform Abstract The title compounds (II), (III), and (IV), synthesized by oxidative alkaline or acidic ring closure reaction of the hydroxychalcones (I) are screened for their antibacterial and antifungal activity against Staph. aureus, Esch. coli and Asperg. niger. They have only moderate activity.

Synthesis and Structured N-Acyl and Thiourea Derivatives Citizine and Anabazine

“…(J, Hz): 1.31-1.52 m (1Н. Н 9ax ), 1.53-1.61 m (3Н, Н 8ах,10ах,9eq ), 1.70-1.88 m (1Н, Н 8eq ), 2.18-2.40 m (1Н, Н 10eq ), 2.76-2.84 m (2Н, Н 4ах,7ах ), 2.96-2.98 m (1Н, Н 7eq ), 3.58-3.65 m (2Н, H 4eq,Н-11 ), 4.58 widened singlet (1Н, Н 1 ), 5.12-5.21 m (1Н, Н 5 ), 7.18-7.22 m (3Н, Н 14,15,16 ), 7.25-7.37 m (4Н, Н 13,17,22,23 ), 8.40-8.50 (2Н, Н 19,21 1. 2020 1-(5-Phenyl-4,5-dihydro-1H-pyrazol-3-yl)cytisine (6).…”

“…The cyclocondensation reaction of hydrazines with α, β-unsaturated ketones is an important synthetic approach to the preparation of 1,2-azoles. Some pyrazole derivatives exhibit the properties of analgesics and platelet aggregation inhibitors [18], have a strong antibacterial [19] and anesthetic [20] effect.…”

“…In the 1 H NMR spectrum of compound 7, the piperidine cycle signals manifested themselves as multiplets at 0.99-1.00 (Н 10ax ), 1.31-1.34 (Н 11ax ), 2.52-2.55 ( Н12eq ) and 3.00-3.05 (Н 9ax ) ppm. Unsaturated protons H 18 and H 19 resonated with doublets at 6.87 ( 3 J 16.0 Hz) and 7.65 ( 3 J 15.6 Hz) ppm. Aromatic phenyl and pyridine protons were manifested by broadened singlets at 7.39 (Н 5,22,23,24 ), 7.86 (Н 4 ) and 8.66 (Н 2 ) and doublets at 7.58 (Н 21,25 , 3 J 6.4 Hz) and 8.47 (Н 6 , 3 J 4.1 Hz ) ppm The proton of the H 15 amide bond resonated with a broadened singlet in the weakest field of the spectrum at 10.85 ppm.…”

Synthesis and spectral characterization of some bromo-benzothiazolo pyrazolines

“…In view of the influence of halogen atoms on the biological activity of organic compounds, Ankhiwala [1] synthesized some nuclear halogenated pyrazolines and their derivatives and screened them for their biological activity. These compounds were found to be active against Staphylococcus aureus and Escherichia coli.…”

Synthesis and antimicrobial activity of some bromo-benzothiazolo pyrazolines

“…Antibacterial activity of some fluorine containing 2-Pyrazolines has been studied recently [4]. In view of the influence of halogen atoms on the biological activity of organic compounds [5], Ankhiwala [6] synthesized some nuclear halogenated pyrazolines and their derivatives and screened them for their biological activity. In continuation of our previously synthesized pyrazolines [7], we have now synthesized bromopyrazolines by the bromination of pyrazolines to study the effect of bromine on their biological activity.…”