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BackgroundIn order to obtain biomaterials with controllable physicochemical properties, hybrid biomaterials composed of biocompatible biopolymers and ceramic nanoparticles have attracted interests. In this study, we prepared biopolymer/ceramic hybrids consisting of various natural biopolymers and layered double hydroxide (LDH) ceramic nanoparticles via an electrophoretic method. We studied the structures and controlled-release properties of these materials.Results and discussionX-ray diffraction (XRD) patterns and X-ray absorption spectra (XAS) showed that LDH nanoparticles were formed in a biopolymer hydrogel through electrophoretic reaction. Scanning electron microscopic (SEM) images showed that the ceramic nanoparticles were homogeneously distributed throughout the hydrogel matrix. An antioxidant agent (i.e., ferulic acid) was loaded onto agarose/LDH and gelatin/LDH hybrids, and the time-dependent release of ferulic acid was investigated via high-performance liquid chromatography (HPLC) for kinetic model fitting.ConclusionsBiopolymer/LDH hybrid materials that were prepared by electrophoretic method created a homogeneous composite of two components and possessed controllable drug release properties according to the type of biopolymer.

We have prepared organic-inorganic hybrid materials consisting of layered metal hydroxides and hydrogel polymers for potential use as a drug delivery system. The hybrid materials were synthesized by an electrophoretic method; anionic precursors, OH -/CO 3 2-, and cationic metal Zn 2+ were migrated into hydrogel by applying an electrical potential of 25 V for 20 min to form inorganic nanocrystals inside the hydrogel matrix. Hydrozincite [Zn 5 (OH) 8 (CO 3 )] nanoparticles, a kind of layered metal hydroxide, were determined to develop [a]

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