Ibuprofen (IBU) is an anti-inflammatory drug characterized by low solubility and bioavailabilty. This study was to develop IBU-liposphere and investigated for in vitro and in vivo performance. IBU free base was incorporated into lipospheres based on micronized beeswax and Phospholipon ® 90H in the ratio of (1:3), via hot emulsification. IBU-loaded lipospheres were characterized based on morphology, encapsulation efficiency (EE%), and in vitro drug release. Analgesic, anti-inflammatory activities and the pharmacokinetics were similarly evaluated. Minimum and maximum encapsulation efficiency (EE%) of 89.4 and 97.9% were obtained for lipospheres A1 and A3, respectively. Stable, spherical and smooth lipospheres of size range 101 ± 0.30 to 178 ± 0.30 µm were obtained. Minimum and maximum release of 75 and 96.9% were obtained for A1 and A3, respectively. Significant (p<0.005) analgesic and anti-inflammatory activities were achieved with prolong plasma concentration. IBU-lipospheres based on beeswax and phospholipid could be explored as an alternative drug delivery system.
Pregelatinised maize starch was prepared from evaporating to dryness 8%w/v of maize starch mucilage and pulverising it. Its physicochemical properties were compared with maize starch powder. Its higher and tapped densities resulted in lower Carr's index. Its higher particle flow rate lower angle of reponse could render it a better candidate in capsule filling and tablet compression. The later properties could allow more uniform dose distribution by weight and lower power consumption for compression. Its higher intraparticulate porosity and more amorphous disruption by the gelatinisation could cause dose form faster disentegration and therefore enhanced faster dissolution for faster drug bioavailability.
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