Formulation and Evaluation of Ibuprofen Loaded Lipospheres for Effective Oral Drug Delivery

Momoh, Mumuni A.; Kenechukwu, FC; Gwarzo,; Builders, Philip F.

doi:10.3329/dujps.v14i1.23730

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…Solid lipid lipospheres have earlier been investigated as a system for oral drug delivery of insulin using a methacrylic acid-based microparticulate hydrogel formulation [ 9 ]. Similarly, previous researchers have reported the delivery of ibuprofen using synthetic lipid materials [ 10 ]. Irvingia wombolu (Irvingiaceae) is a tropical African tree that grows in local settings across West and Central Africa and is used extensively as fruit and a thickener in food preparations [ 11 ].…”

Section: Introductionmentioning

confidence: 84%

Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids

Gugu

Agu

Uronnachi

et al. 2023

BMC Complement Med Ther

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Ibuprofen is a member of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAIDs) with anti-inflammatory, analgesic, and antipyretic activities used to relieve a variety of pains. The objective of this study was to formulate, characterize and evaluate the in vitro and in vivo properties of ibuprofen formulated as solid lipid microspheres (SLMs) for enhanced delivery. The mixtures of Irvingia wombolu fat (IRW) and moringa oil (MO) each with Phospholipon® 90G (PL90G) at the ratio of 2:1 w/w were prepared by fusion, characterized and used to prepare SLMs. The SLMS were thereafter evaluated using the following parameters: particle size and morphology, stability, and encapsulation efficiency EE (%). In vitro release was carried out in phosphate buffer (pH 7.4). The ibuprofen based SLMs were also evaluated for anti-inflammatory and anti-ulcer effects using animal models. The pH showed significant increase after two months of formulation with a maximum value of 6.4 while the EE obtained were 95.6, 89.4 and 61.6% for SLMs formulated with lipid matrix of Phospholipon® 90G (1% and 2%), and MO (1%) respectively. The in vitro release showed maximum release of 87.8 and 98.97% of the two different lipid-based formulations while anti-inflammatory effect was up to 89.90% after 5 h of inducing inflammation. The SLMs did not show any lesion thus conferring gastroprotection on the formulations. The SLMs exhibited good anti-inflammatory property with gastroprotective action.

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Section: Introductionmentioning

confidence: 84%

Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids

Gugu

Agu

Uronnachi

et al. 2023

BMC Complement Med Ther

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“…Method of incorporation and the nature of interaction between the model drug and the encapsulating matrix are some of the factors that affect EE%. It can be seen from Table 2 that the various formulations studied were [17]. One other parameter that affects EE% when total amount of drug used is constant is the lipid concentration.…”

Section: Discussionmentioning

confidence: 99%

Beeswax-Lecithin SLMs of Erythromycin Ethyl Succinate for Treatment of Acute Bacteremia in Infected Mice

Osonwa¹,

Uwaezuoke²,

Ilunoh³

2016

JCCE

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Abstract:The aim of this work was to increase the efficacy of erythromycin ethyl succinate by encapsulation in beeswax lipid matrix using Myrj 52 as emulsifier. Different batches of SLM's (solid-lipid microparticles) were formulated and stable ones were selected. The encapsulation efficiency and loading capacities were calculated. The batch with the highest loading capacity was used for further assays. The particle size was determined by light microscopy. The sensitivity of different clinical bacterial isolates to erythromycin was tested using in vitro cultures and E. coli was selected for efficacy tests. The activity of the formulated drug was tested in the in vitro culture and compared to that of the unformulated drug. White albino mice were infected with E. coli and left for one day to develop significant bacteremia. They were then divided into 4 groups (n = 4) and treated with the formulation and unformulated drug at a dose of 7.14 mg/kg 8 hourly for 56 hours. A third group was given SLM's that do not contain drug, while another group was left untreated. The selected batch has an encapsulation efficiency of 94.83% with a loading capacity of 3.88%. The particle size was 17 ± 4 µm. At the end of the three day period of treatment, the group treated with unformulated erythromycin had much stooling and weakness in the mice, and some deaths were recorded, while that treated with the formulation had 33.8% bacteremia and the clinical signs had largely subsided. The other two groups recorded deaths the following day after bacteremia induction. The results show marked improvement in efficacy of erythromycin ethyl succinate by formulation in SLMs with beeswax and lecithin as lipid matrix.

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“…Although hyperlipidemia does not cause to feel bad, it can significantly increase the risk of developing coronary heart disease, also called coronary artery disease or coronary disease. People with coronary disease develop thickened or hardened arteries in the heart muscle 6 . This can cause chest pain, a heart attack, or both.…”

Section: Figure 1: Hypercholesterolemiamentioning

confidence: 99%

Formulation Development and Evaluation of Liposphere of Poor Water Soluble Drug for Hyperlipidemia

Kumar¹,

Jain²,

Patel³

2021

J. Drug Delivery Ther.

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Lipospheres offer a new approach to improve an aqueous solubility of BCS class-II drugs. Simvastatin is a third generation fibric acid derivative belonging to this class, employed clinically as a hypolipidemic agent to lessen the risk caused by atherosclerosis. An attempt was made to improve aqueous solubility of Simvastatin by aid of stearic acid and Paraffin oil. The factorial batches of the Simvastatin lipospheres were formulated by melt dispersion technique using 32 factorial design with variables X1- concentration of stearic acid and X2- concentration of paraffin oil and responses Y1 - % Drug Entrapment (% DE) and Y2 - % Drug Release (% DR). From the surface response graphs the optimized batch was formulated and evaluated for saturation solubility, in-vitro drug release studies. Significant improvement in the aqueous solubility of the drug in the Simvastatin lipospheres supports the applicability of lipospheres as a tool for improving aqueous solubility of the BCS class-II drugs. Keywords: Linospheres; Simvastatin; Drug release; Hyperlipidemic; Drug entrapment.

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Formulation and Evaluation of Ibuprofen Loaded Lipospheres for Effective Oral Drug Delivery

Cited by 7 publications

References 26 publications

Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids

Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids

Beeswax-Lecithin SLMs of Erythromycin Ethyl Succinate for Treatment of Acute Bacteremia in Infected Mice

Formulation Development and Evaluation of Liposphere of Poor Water Soluble Drug for Hyperlipidemia

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