ObjectiveTo detect the presence and concentration of methylparaben in cartridges of
commercial Brazilian local anesthetics.Material and methodsTwelve commercial brands (4 in glass and 8 in plastic cartridges) of local
anesthetic solutions for use in dentistry were purchased from the Brazilian market
and analyzed. Different lots of the commercial brands were obtained in different
Brazilian cities (Piracicaba, Campinas and São Paulo). Separation was performed
using high performance liquid chromatography (HPLC) with UV-Vis detector. The
mobile phase used was acetonitrile:water (75:25 - v/v), pH 4.5, adjusted with
acetic acid at a flow rate of 1.0 ml.min-1. ResultsWhen detected in the solutions, the methylparaben concentration ranged from 0.01%
(m/v) to 0.16% (m/v). One glass and all plastic cartridges presented
methylparaben. Conclusion1. Methylparaben concentration varied among solutions from different
manufacturers, and it was not indicated in the drug package inserts; 2. Since the
presence of methylparaben in dental anesthetics is not regulated by the Brazilian
National Health Surveillance Agency (ANVISA) and this substance could cause
allergic reactions, it is important to alert dentists about its possible
presence.
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