Latar Belakang: Gejala klinis lupus eritematosus sistemik (LES) menunjukkan variabilitas yang besar, dengan proses autoimun yang mendasarinya. Interleukin-1 (IL-1) adalah sitokin pleiotropik yang telah dikaitkan dengan imunopatogenesis SLE dan tingkat keparahan penyakitnya. Selain itu, telah ditunjukkan bahwa IL-1 memainkan peran penting dalam nefritis lupus. Tujuan: Untuk mengetahui hubungan antara laju filtrasi glomerulus (LFG) dan interleukin 1 (IL-1) serum pada pasien SLE. Metode : Dari Januari hingga Maret 2018, sebuah studi potong lintang analitik observasional dilakukan di poliklinik penyakit dalam dan bangsal rawat inap di Rumah Sakit Sanglah Denpasar di Bali, Indonesia. Pasien SLE perempuan yang berusia di atas 18 tahun, tidak dalam masa menopause, dan bersedia berpartisipasi dilibatkan dalam penelitian ini. Tes imunosorben terkait-enzim (ELISA) dengan sensitivitas tinggi digunakan untuk mengukur kadar IL-1 darah. Usia, Indeks Massa Tubuh (BMI), skor MEX-SLEDAI, kreatinin serum, dan Glomerular Filtration Rate (GFR) data diperoleh dari wawancara dan tinjauan catatan medis. Hasil: Studi ini melibatkan 54 peserta, dengan usia rata-rata 28,43+6,58. Kadar IL-1 serum ditentukan rata-rata 0,16 (0,06-0,95) pg/ml. IL-1 dan GFR terbukti berkorelasi secara signifikan (r=0,338; P=0,012). Simpulan: Penelitian ini menunjukkan hubungan antara IL-1 serum dan laju filtrasi glomerulus pada LSE yang tidak aktif.
Travel Medicine is one branch of medicine which specializes in preventing and treating medical problems for travelers especially when they are traveling. It is undeniable that there are differences in medical knowledge between developing and developed countries when dealing with traveler’s health problems. The purpose of this study is to comprehend the characteristics and health problems of travelers who visited Sanglah General Hospital between 2017 and 2019. This is a descriptive study which used consecutive sampling in every medical record of the patients to study their health problems. Every medical record recorded the name, age, sex, health insurance, inpatient or outpatient, and diagnosis of the patients. As many as 618 subjects’ medical record number was conducted at first with dominantly men (55.2%) and women (44.8%). The mean age of this study was 42,76 years old with the eldest age being 92 years old and the youngest being 18 years old. As many as 328 subjects (53.1%) of this study did not use health insurance and only 290 subjects (46.9%) used health insurance. The number of outpatients, which was 564 subjects (91.3%), was much more than the number of inpatients in this study. Frequent health problems that subjects suffered were malignancy (solid and hematologic) 116 subjects (18.7%), kidney problem 107 subjects (17.3%), and accident (wounds, fracture and head trauma) 44 subjects (7.1%). Descriptive study among travelers is not usually done in our hospital and this is an elementary study so that in the future there will be more study for travelers.Keywords: Travel medicine; Travel; Tourism.
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