In the present study, the facile and synergistic approach for electrochemical sensing of paracetamol (PA) drug was demonstrated by hydrothermally synthesized copper oxide-copper ferrite nanohybrid composite supported on reduced graphene oxide (CuO-CuFe2O4@rGO) glassy carbon electrode. The surface texture and structural information of the electrode material were examined by FE-SEM, HR-TEM, and X-ray diffraction techniques, whereas the electrochemical sensing application of paracetamol oxidation was investigated by cyclic voltametry method. The average crystallite size of CuO-CuFe2O4 was calculated from XRD data and found to be 35.45 nm. The fabricated sensor exhibited a higher sensitivity of 970.26 µA.mM-1.cm-2along with a lower limit of detection (LOD) and limit of quantification (LOQ) of 7.0 µM and 25 µM, respectively, with a linear dynamic range of 10 - 1200 µM. Furthermore, the CuO-CuFe2O4@rGO modified sensor showed excellent anti-interferents ability, long-term stability and reproducibility towards electro-oxidation of paracetamol drug. Moreover, it can be efficiently applied for the analysis of paracetamol in biological samples. Finally, the synthesized nanocomposite material was validated to be a competent electro-catalyst for electrochemical sensing application of paracetamol.
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