Caffeine is a highly-consumed substance around the world and can be found in various food sources and certain medications. The present systematic review aimed to evaluate the effect of caffeine on bone metabolism in rats. A systematic review was conducted in the PubMed, Medline, Scopus, Cocharane, Embase, and Clinical Trials.gov databases, and the Guidelines for Preferential Reporting for Systematic Reviews and Meta-Analyzes (PRISMA) were followed. In vivo experimental studies that presented caffeine as the study object were included, and studies which did not evaluate the bone metabolism and/or evaluated the caffeine in association with other substances were excluded. The quality evaluation of the selected studies was carried out following the guidelines of the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) and the Animal Research Reporting In Vivo Experiment (ARRIVE). Nine of the 472 initially identified articles met the inclusion criteria and were selected for qualitative evaluation. There was a variation between the included studies regarding the administered caffeine doses in each experimental group, as well as their frequency and duration of ingestion. Most studies show that caffeine can interfere with bone metabolism, be it in a negative way by accelerating bone loss and delaying bone repair, or in a beneficial way by activating osteogenesis and bone neoformation. There is a need for further studies to better understand the real effect of caffeine on bone metabolism.
HIGHLIGHTS Nine of 472 initially identified articles were selected for qualitative evaluation. Most studies show that caffeine can interfere with bone metabolism. Caffeine can accelerate bone loss and delay bone repair. In contrast, caffeine can activate osteogenesis and bone neoformation. 2 Moreno, M.C.; et al.
Diante das mais variadas técnicas ortodônticas existentes na Ortodontia, a técnica 3DBOT (Tratamento Tridimensional Ortodôntico sem Bráquetes) se destaca por utilizar a tecnologia, o set up 3D, de forma obrigatória. Por definição, a técnica possibilita movimentos nas três dimensões do espaço, com alta previsibilidade dos movimentos, não necessitando dos bráquetes como suporte para a correção dentária. Os alinhadores asseguram o controle dos torques e um excelente detalhamento final. O presente estudo visa descrever um caso clínico de Classe I de Angle, com apinhamentos dentários, tratada com a técnica fixa 3DBOT e alinhadores. Os resultados foram alcançados na primeira etapa com duração de 8 meses, seguidos dos alinhadores finais por 3 meses. A técnica 3DBOT demonstrou ser uma opção eficaz, eficiente e principalmente confortável.
Class II represents a considerable part of orthodontic problems to be treated in dental clinics. To correct this malocclusion, there are currently several forms of treatment. Among the functional orthopedic devices, the Herbst device has stood out due to its efficiency and practicality for being fixed and not requiring the collaboration of the patient. The purpose of this article is to present, through a clinical case report, the treatment of class II malocclusion with a modified Herbst appliance with a lower acrylic splint. The female patient initially had 11 years and 11 months, permanent dentition, mandibular retrusion and atresia of the arches. Initially, a maxillary circuit breaker and lower expander were used, followed by the Herbst appliance and finished with fixed orthodontics. At the end of the treatment, the modified Herbst appliance proved to be effective, providing a class I molar relationship, improving the patient’s profile and decreasing the space between the resting lips.
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