Taking a plateau high-pressure common-rail diesel engine as the research model, a model was established and simulated by AVL FIRE according to the structural parameters of a diesel engine. The combustion and emission characteristics of D, B20, and B50 diesel engines were simulated in the plateau atmospheric environment at 0 m, 1000 m, and 2000 m. The calculation results show that as the altitude increased, the peak in-cylinder pressure and the cumulative heat release of diesel decreased with different blending ratios. When the altitude increased by 1000 m, the cumulative heat release was reduced by about 5%. Furthermore, the emission trend of NO, soot, and CO was to first increase and then decrease. As the altitude increased, the mass fraction of NO emission decreased. As the altitude increased, the mass fractions of soot and CO increased. Additionally, when the altitude was 0 m and 1000 m, the maximum temperature, the mass fraction of OH, and the fuel–air ratio of B20 were higher and more uniform. When the altitude was 2000 m, the maximum temperature, the mass fraction of OH, and the fuel–air ratio of B50 were higher and more uniform. Lastly, as the altitude increased, the maximum combustion temperature of D and B20 decreased, and combustion became more uneven. As the altitude increased, the maximum combustion temperature of B50 increased, and the combustion became more uniform. As the altitude increased, the fuel–air ratio and the mass fractions of OH and NO decreased. When the altitude increased, the soot concentration increased, and the distribution area was larger.
The burner-type regeneration diesel particulate filter is one of the most widely used diesel particulate filters. Using AVL FIRE, a 3D model of a burner-type regeneration diesel particulate filter (DPF) was established, and simulation analyses were carried out. The effects of the exhaust parameters (temperature, exhaust mass flow rate, and soot load) and the structural parameters (channel density, inlet/outlet channel ratio, and the length–diameter ratio) on soot distribution (soot mass concentration and soot thickness) were analyzed. The results show that the soot distribution characteristics of regenerative DPF with a burner are as follows: the soot mass concentration first rapidly rises to the maximum value and then rapidly decreases to a low value, and the dust thickness gradually increases with the increase in location. With the increase in exhaust mass flow rate and soot load, soot mass concentration and soot thickness increase. With the increase in temperature, the mass concentration and thickness of the ash decreased. When the temperature exceeds 750 K, soot begins to regenerate. Among the exhaust parameters, the mass flow rate of the exhaust has the greatest influence on the soot distribution. The length–diameter ratio, the ratio of the inlet and the outlet channel, and channel density have little effect on the mass concentration of soot, and the soot mass concentration increases with the increase in channel density. In addition to the length–diameter ratio of 2.1, the soot thickness increases with the increase in the length–diameter ratio, and the rising rate is also accelerated. The thickness of soot decreased with the increase in channel density and the ratio of the inlet and the outlet channels. When the channel density is more than 250, the change in soot thickness is basically the same. When the ratio of the inlet and the outlet channels exceeds 1.3, the change in the soot thickness is basically the same. Among the structural parameters, channel density has the greatest influence on the soot distribution.
Cyclone venturi dryer is suitable for drying materials with large particle size and wide distribution. The working process of cyclone venturi dryer is a very complicated three-dimensional and turbulent motion, so it is difficult to be studied theoretically and experimentally. In order to study the internal flow characteristics of the biomass particle cyclone venturi dryer, the computational fluid dynamics (CFD) software was used to simulate the gas-solid two-phase flow field inside the cyclone venturi dryer. The continuous phase adopts the Realizable k-ε turbulence model and the particle phase is discrete. The effects of different injection volume on the pressure, velocity, and temperature fields inside a cyclone venturi dryer were analyzed. The results showed that the maximum pressure drop and velocity change inside the dryer were at the venturi pipe. The wet material of the cyclone venturi dryer was inhaled into the venturi contraction tube by the negative pressure formed after the highspeed airflow was ejected, thus the mixture was completed in the venturi throat. The wood debris material was mixed with the high-speed hot gas flow in the venturi throat and then sprayed into the diffusion pipe. In the diffusion pipe of venturi, the heat and mass transfer process of wet wood debris and heat flow in venturi diffusion tube was completed. It is in good agreement with the simulation results. This study can provide a reference for the optimization design of the related cyclone venturi dryer structure.
Krabbe disease is caused by the mutation or deficiency of galactocerebrosidase (GALC) enzyme, which is located in the lysosome and hydrolyzes the galactolipid substrates like psychosine. Psychosine would accumulate abnormally in the myelin forming cells and result in demyelination in the nervous systems with the clinical symptoms of spastic paraparesis and seizures. Adeno-associated virus (AAV) is a well-established and safe viral vector for gene delivery. However, effective AAV serotype for the transduction of the human neural stem cells (NSCs) has not been identified. Here, we screened a variety of AAV serotypes to transduce NSCs-related disease model induced by Krabbe patient induced pluripotent stem cells (iPSC) differentiation. It has been found that AAV2 has a higher transduction effect for NSCs, and AAV2 carrying GALC gene rescued the GALC enzymatic activity of Krabbe NSCs. Our findings established Krabbe patient iPSCs-derived NSCs as a new model for study the pathogenesis of Krabbe disease, and also demonstrated the potential of using AAV2 as a vector in gene therapy for Krabbe disease, which also proved the potential of AAV in devising gene therapy strategies for the treatment of genetic neurodegenerative diseases.
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