A single treatment of 20 U of BoNTA was effective and safe in reducing glabellar lines in Chinese subjects.

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It is unclear whether siRNA-based agents can be a safe and effective therapy for diseases. In this study, we demonstrate that microphthalmia-associated transcription factor-siRNA (MITF-siR)-silenced MITF gene expression effectively induced a significant reduction in tyrosinase (TYR), tyrosinase-related protein 1, and melanocortin 1 receptor (MC1R) levels. The siRNAs caused obvious inhibition of melanin synthesis and melanoma cell apoptosis. Using a novel type of transdermal peptide, we developed the formulation of an MITF-siR cream. Results demonstrated that hyperpigmented facial lesions of siRNA-treated subjects were significantly lighter after 12 weeks of therapy than before treatment (P < 0.001); overall improvement was first noted after 4 weeks of siRNA treatment. At the end of treatment, clinical and colorimetric evaluations demonstrated a 90.4% lightening of the siRNA-treated lesions toward normal skin color. The relative melanin contents in the lesions and adjacent normal skin were decreased by 26% and 7.4%, respectively, after treatment with the MITF-siR formulation. Topical application of siRNA formulation significantly lightens brown facial hypermelanosis and lightens normal skin in Asian individuals. This treatment represents a safe and effective therapy for melasma, suggesting that siRNA-based agents could be developed for treating other diseases such as melanoma.

Calcitriol administered twice daily over a 12-week treatment period demonstrated similar efficacy to calcipotriol, while showing a significantly better safety profile.

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The severity of climate change and the urgency of ecological environment protection make the transformation of coal power imperative. In this paper, the relevant policies of coal-biomass co-firing power generation are combed, and the technical and economic evaluation of coal-biomass co-firing power generation technology is carried out using Levelized Cost of Electricity (LCOE) model. The result is that the LCOE of coal-biomass indirect co-firing power generation project is significantly higher than that of the pure coal-fired unit, with the LCOE rising by nearly 8%. Through sensitivity analysis, the LCOE will increase by 10.7% when it combusts 15% biomass, and increase by 19.1% when it combusts 20% biomass. The LCOE corresponding to wood chips increased by 5.71% and the LCOE to rice husks decreased by 6.06%. Finally, this paper puts forward some relevant policy suggestions, hoping to provide some reference for the promotion of coal-biomass co-firing power generation in China.