The new device can be applied to an overwhelming majority of patients with phimosis and excess foreskin. This technique is relatively simple to perform, and patients who underwent this surgery had very few complications. Antibiotics were not required and patients reported less pain than those who were circumcised using conventional methods. Circumcision with this device requires minimal tissue manipulation, and is quicker and safer than circumcision using conventional techniques.
Prostate cancer (PCa) is the most common malignancy among males worldwide, and is one of the leading causes of cancer-related mortality. MicroRNAs (miRs) are a type of endogenous, noncoding RNA that serve a key role in pathological processes, and have been demonstrated to be involved in the formation and progression of PCa. Previous studies have reported that miR-106b acts as an oncogene; however, the specific effects of miR-106b on PCa have not been fully elucidated. The present study aimed to investigate the role and underlying molecular mechanisms of miR-106b in the initiation and progression of PCa. In this study, miR-106b was reported to be overexpressed and la-related protein 4B (LARP4B) was downregulated in PCa tissues compared with paracancerous tissues. In addition, LARP4B was identified as a target gene of miR-106b by bioinformatics prediction analysis and a dual luciferase reporter gene assay. Furthermore, MTT, wound healing and Transwell assays were performed to evaluate PCa cell viability, and migration and invasive abilities. The data revealed that inhibition of miR-106b significantly suppressed the viability, migration and invasion of PCa cells. In addition, inhibition of miR-106b significantly suppressed the mRNA and protein expression of cancer-related genes, including matrix metalloproteinase-2, cluster of differentiation 44 and Ki-67, and increased that of the tumor suppressor, mothers against decapentaplegic homolog 2. Collectively, the findings of the present study indicated that miR-106b may target LAR4B to inhibit cancer cell viability, migration and invasion, and may be considered as a novel therapeutic target in PCa.
Two nitrification‐denitrification systems were used to determine the possible inhibitory and/or toxic effects of supplementa metals addition to the nitrification‐denitrification process in the treatment of a relatively high ammonia, low biodegradable carbon, municipa landfill leachate. The addition of metals likely resulted in the precipitation of phosphorus which caused the nitrification‐denitrification process to be inhibited due to the deficiency of bioavailable phosphorus. Even though the phosphorus concentrations in mixed liquor and system effluent samples filtered through Whatman No. 4 filters or glass‐fiber filters appeared to be adequate, it was discovered that they were considerably lower when filtered through 0.45‐µm membrane filters. This seemed to indicate that although some of the precipitated phosphorus passed through the Whatman No. 4 filter, it was not available as a nutrient for microbial metabolism. Therefore, only the phosphorus that will pass through a 0.45‐µm membrane filter, and is defined as soluble in Standard Methods (1985) is readily available to the microorganisms. This should be monitored ensure sufficient nutrient availability in nitrification‐denitrification treatment systems potentially exposed to metals capable of precipitating phosphorus. It is recommended that a minimum soluble phosphorus concentration of 0.5 mg/L be maintained to ensure adequate phosphorus for nitrification and denitrification; in addition, when conducting activated sludge metal toxicity studies, total or Whatman No. 4‐filtered samples should not be used to determine the presence of adequate phosphorus.
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