The nature of muscle‐bone crosstalk has been historically considered to be only mechanical, where the muscle is the load applier while bone provides the attachment sites. However, this dogma has been challenged with the emerging notion that bone and muscle act as secretory endocrine organs affect the function of each other. Biochemical crosstalk occurs through myokines such as myostatin, irisin, interleukin (IL)‐6, IL‐7, IL‐15, insulin‐like growth factor‐1, fibroblast growth factor (FGF)‐2, and β‐aminoisobutyric acid and through bone‐derived factors including FGF23, prostaglandin E2, transforming growth factor β, osteocalcin, and sclerostin. Aside from the biochemical and mechanical interaction, additional factors including aging, circadian rhythm, nervous system network, nutrition intake, and exosomes also have effects on bone‐muscle crosstalk. Here, we summarize the current research progress in the area, which may be conductive to identify potential novel therapies for the osteoporosis and sarcopenia, especially when they develop in parallel.
In order to investigate Ca evaporation behavior in the electron beam melting process, metallurgical-grade silicon was melted in an electron beam furnace with different experimental conditions. The results showed that the content of impurity Ca was significantly decreased in the early time, while these changed slowly with the extension of the melting. The removal rate of Ca was controlled by the transfer of Ca atoms from the bulk liquid silicon to liquid/gas phase interface within the range of experiment temperature.
Currently, the application of bag-filter technology in controlling diesel exhaust particulate emissions has been close to practical stage. As one of the key links in bag-filter technology, engine exhaust cooling can directly influence working safety of the entire exhaust particulate filter system. Thermodynamic calculations and experimental research of water-cooled chiller has provided a feasible basis for water cooler to be used in actual diesel exhaust particulate emission control system. The cooler can make engine exhaust temperature drop from 400 to 180 . Even when engine works in high-speed and high-load condition, inlet exhaust temperature of cooler can descend from 500 to 190 or so after cooling, which can still meet bag-filter system requirement of below 200 .
The growth in the solar energy technology caused inshortage solar grade Si. As a lowcost, environmental friendly technology, metallurgical method purity silicon is developed significantly. However, as a typical impurity in Si, B is difficult to be removed by directional refining or vacuum melting due to its large segregation coefficient and less evaporation coefficient. In this paper, the big difference of evaporation pressure between Si and B can be applied to separate B from Si, in which, B is remained in molten Si, while most of Si becomes evaporant. Electron beam is applied to scan molten Si and the Si existed in the form of the evaporant is gather on the watercooled crystallizer. The content B in the evaporant is undetectable by ICP-MS.
In production process of continuous casting slab in ferrous metallurgy, in order to realize soft reduction and obtain continuous casting slabs without internal defects, it is important to determine the location of final solidifying end of slabs exactly. In this paper, a set of physical simulation device which simulates detecting the final solidifying end was designed according to similarity theory. Through experimental study and mathematical statistic method, we analyzed the influence of each factor on the detected results. The research results may provide certain guidance for the on-line detection final solidifying end in situ.
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