Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis

Li, Guo Bin; Zhang, Lan; Wang, Dong En; AIQudsy, Luban; Jiang, Jean X.; Xu, Hui; Shang, Peng

doi:10.1002/jcb.28946

Cited by 105 publications

(95 citation statements)

References 122 publications

(203 reference statements)

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“…Glucocorticoids (GC) might be a common and potentially pathologic regulatory link between muscle and bone regeneration, since FGF-2 rescues both the deleterious effects of GC on myostatin and SOST expression [80]. Members of the FGF family exert multiple functions in bone and muscle [81,82]. The FGF23 is a member of the endocrine subfamily of FGFs that regulates phosphate excretion in the kidney and the intestinal phosphate uptake via the downregulation of 1α-hydroxylase, the vitamin D-activating gatekeeper enzyme.…”

Section: Bone Secretory Products With Endocrine Functionsmentioning

confidence: 99%

“…IGF-1 and also FGF2 are growth factors that are actively secreted at the muscle and bone interface and if delivered into the circulation may have distant effects on bone formation and remodeling. Irisin, a cleaved product of fibronectin type III domain containing (FNDC5) with stimulating effects on bone formation, is also delivered from muscle into the circulation after exercise but may have a dual mode of delivery, shedding of preformed polypeptides and de novo synthesis [81].…”

Section: Muscle Secretory Products With Endocrine Functionsmentioning

confidence: 99%

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Interactions between Muscle and Bone—Where Physics Meets Biology

et al. 2020

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Muscle and bone interact via physical forces and secreted osteokines and myokines. Physical forces are generated through gravity, locomotion, exercise, and external devices. Cells sense mechanical strain via adhesion molecules and translate it into biochemical responses, modulating the basic mechanisms of cellular biology such as lineage commitment, tissue formation, and maturation. This may result in the initiation of bone formation, muscle hypertrophy, and the enhanced production of extracellular matrix constituents, adhesion molecules, and cytoskeletal elements. Bone and muscle mass, resistance to strain, and the stiffness of matrix, cells, and tissues are enhanced, influencing fracture resistance and muscle power. This propagates a dynamic and continuous reciprocity of physicochemical interaction. Secreted growth and differentiation factors are important effectors of mutual interaction. The acute effects of exercise induce the secretion of exosomes with cargo molecules that are capable of mediating the endocrine effects between muscle, bone, and the organism. Long-term changes induce adaptations of the respective tissue secretome that maintain adequate homeostatic conditions. Lessons from unloading, microgravity, and disuse teach us that gratuitous tissue is removed or reorganized while immobility and inflammation trigger muscle and bone marrow fatty infiltration and propagate degenerative diseases such as sarcopenia and osteoporosis. Ongoing research will certainly find new therapeutic targets for prevention and treatment.

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Section: Bone Secretory Products With Endocrine Functionsmentioning

confidence: 99%

Section: Muscle Secretory Products With Endocrine Functionsmentioning

confidence: 99%

Interactions between Muscle and Bone—Where Physics Meets Biology

et al. 2020

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“…The cross-talk between bone and muscle is receiving increased attention as it may have a role in health maintenance and decline [24][25]. Dysregulation in bone-muscle cross-talk can influence the progression of osteoporosis and sarcopenia [26] conditions often seen in frailty [27,28]. Pre-frail and frail individuals are at increased risk for osteoporotic fracture [29,30] and have been shown to present with reduced bone health [31,32].…”

Section: Introductionmentioning

confidence: 99%

Bone Metabolism Analytes as Biomarkers of Pre-Frailty and Cardiovascular Disease Risk in Females

2020

Adv Geriatr Med Res

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Background: Frailty and cardiovascular disease (CVD) share common pathophysiology in their progression. Declines in bone health often occur concomitantly with frailty and CVD. Therefore, analytes of bone metabolism may be useful biomarkers of pre-frailty and CVD risk. The aim of this study was to identify the effects of pre-frailty and CVD risk on the systemic concentrations of bone metabolism and inflammatory analytes in middle-aged and older females. Method: This case-control study is a secondary analysis of data from 1030 females with no self-reported history of CVD. Frailty was measured using the Fried Criteria, and females were stratified into low and elevated CVD risk using the Framingham risk score. Greedy matching with pre-frailty as the exposure variable identified 26 matched pairs in the low and elevated CVD risk groups for a total of 104 females. Factorial ANOVA compared differences in the log transformed concentrations of 15 bone metabolism analytes based on pre-frailty status, CVD risk, and the interaction. Results: Differences in the systemic concentrations of IL-6 (5.25 ± 14.30 vs 1.35 ± 1.74 pg/mL, p = 0.001), TNFα (1.41 ± 1.83 vs 0.89 ± 0.40 pg/mL, p = 0.06), and leptin (12628.48 ± 10472.90 vs 7562.96 ± 4972.25 pg/mL, p = 0.023) were found in elevated CVD risk status compared to low. No differences in the concentrations of bone metabolism analytes were found based on prefrailty status, nor were any interaction effects. Conclusion: Differences were found in the concentrations of cytokines involved in bone metabolism based on CVD risk; however, no differences

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“…Mechanical loading is the key mechanism that links both tissues, with cross-talk being made possible by the production and release of growth factors and myokines from skeletal muscle fibers and osteokines secreted by osteoblasts and osteocytes [82]. Bone and muscle health affect each other through the secretion of myokines such as myostatin, irisin, interleukin (IL)-6, IL-7, IL-15, IGF-1, fibroblast growth factor (FGF)-2, and βaminoisobutyric acid and through bone-derived factors including FGF23, prostaglandin E2, transforming growth factor β, osteocalcin, and sclerostin [83]. This tissue cross-talk ensures proper alignment between tissue remodeling and, as such, represents a key factor in maintaining bone and muscle health.…”

Section: Protein Quality and Dairy Matrix Effects On Skeletal Musclementioning

confidence: 99%

Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps

et al. 2019

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Dairy products are included in dietary guidelines worldwide, as milk, yoghurt, and cheese are good sources of calcium and protein, vital nutrients for bones and muscle mass maintenance. Bone growth and mineralization occur during infancy and childhood, peak bone mass being attained after early adulthood. A low peak bone mass has consequences later in life, including increased risk of osteoporosis and fractures. Currently, more than 200 million people worldwide suffer from osteoporosis, with approximately 9 million fractures yearly. This poses a tremendous economic burden on health care. Between 5% and 10% of the elderly suffer from sarcopenia, the loss of muscle mass and strength, further increasing the risk of fractures due to falls. Evidence from interventional and observational studies support that fermented dairy products in particular exert beneficial effects on bone growth and mineralization, attenuation of bone loss, and reduce fracture risk. The effect cannot be explained by single nutrients in dairy, which suggests that a combined or matrix effect may be responsible similar to the matrix effects of foods on cardiometabolic health. Recently, several plant-based beverages and products have become available and marketed as substitutes for dairy products, even though their nutrient content differs substantially from dairy. Some of these products have been fortified, in efforts to mimic the nutritional profile of milk, but it is unknown whether the additives have the same bioavailability and beneficial effect as dairy. We conclude that the dairy matrix exerts an effect on bone and muscle health that is more than the sum of its nutrients, and we suggest that whole foods, not only single nutrients, need to be assessed in future observational and intervention studies of health outcomes. Furthermore, the importance of the matrix effect on health outcomes argues in favor of making future dietary guidelines food based. Keywords Bone. Cheese. Fermented dairy products. Milk. Muscle Abbreviations BMD Bone mineral density BMC Bone mineral content Ca Calcium Ca:P Calcium-to-phosphorus ratio CHD Coronary heart disease The original version of this article was revised due to a retrospective Open Access order.

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Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis

Cited by 105 publications

References 122 publications

Interactions between Muscle and Bone—Where Physics Meets Biology

Interactions between Muscle and Bone—Where Physics Meets Biology

Bone Metabolism Analytes as Biomarkers of Pre-Frailty and Cardiovascular Disease Risk in Females

Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps

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