SummaryObjectives: In this retrospective study, frequency of seizure clustering and occurrence of status epilepticus were investigated in patients with drug resistant focal epilepsy who were admitted in long term video-EEG monitoring unit (VEM) for presurgical evaluation. Methods: The VEM records of 49 patients (26 female, 23 male; mean age 26.35±10.2 years) between April 2004-April 2008 were reviewed. Results: Although there was no status epilepticus occured, seizure clustering was observed in 21 (%42.9) patients during VEM. Conclusion: Seizure clustering was common during presurgical VEM. The risk of seizure clustering might be reduced with a slow antiepileptic drugs tapering protocol and to avoid changing the presently used benzodiazepine dosage.Key words: Antiepileptic drugs; drug resistant epilepsy; seizure clustering; status epilepticus; video-EEG monitoring. ÖzetAmaç: Bu geriye dönük çalışmada dirençli epilepsi tanısı ile takip edilen ve cerrahi öncesi epileptik odağın tespiti amacıyla uzun süreli video-EEG monitorizasyonu (VEM) yapılan hastalarda küme nöbet ve status epileptikus gelişme sıklığı araştırıldı. Sonuç: Küme nöbet cerrahi öncesi video-EEG monitorizasyonu sırasında sık görülür. Bununla birlikte antiepileptik ilaçların yavaş kesilmesi ve kullanılmakta olan benzodiazepin dozunda değişiklikten kaçınılması durumunda küme nöbetlerin gelişme riski azalabilir. Gereç ve
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