A survey was conducted to collect information regarding medicinal and traditional uses of the plant resources from northern areas of Pakistan. Plant species were collected from Gahkuch area, District Ghizer, Gilgit-Baltistan province, Pakistan. A total of 35 plant species belonging to 27 families were found to be commonly used for various medicinal purposes. Among these, 10, 4, 3, 2, 1, 1 and 1 species belonged to families Asteraceae, Cupressaceae, Lamiaceae, Solanaceae, Papilionaceae, Rosaceae and Leguminosae, respectively. Most of the people in the area still depend on herbal medicines for treating different diseases, including asthma, cough, tonic, abdominal pain, jaundice, diarrhea, cancer, headache, diabetes, muscle pain, fever, skin infections, worms, wounds, broken bones, blood pressure, tuberculosis, swellings, anemia, joint pains, inflammation, dyspepsia, arthritis and rheumatism etc. Majority of the medicines prepared by the medicinal plants were taken in direct form, paste form and/or powder form. In some cases, the whole medicinal plants are used while in some other cases, either fruit or leaves/stem or flowers are used as medicine. Besides the use of plants to treat different human diseases, many livestock such as sheep, buffalo, goat and horse were also being treated with herbal medicines. Other than medical use, medicinal plants were also found to be used as fuel, fodder and vegetable/food by local peoples. The people aged 60-80 were found to be the most knowledgeable regarding use of medicinal plants as compared to the younger ones. The major threats to the medicinal palnts of the area were overgrazing, cutting, natural disater and exploitation.