A Review on Secondary Metabolites of Rosa laevigata Michaux: An Important Medicinal Plant

Mehboob, Hira; Iqbal, Muhammad; Ejaz, Muhammad; Bibi, Gulshan; Sarwar, Uzma; Iftikhar, Sadia; Shaheen, Sabah; Safdar, Irum

doi:10.4172/2161-1009.1000326

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Some medically important secondary metabolites with antibacterial, anticancer, astringent, depurative and anti-in ammatory activities: polysaccharides, avonoids, steroids, tannins, laevigatins (E, F, G), triterpenoids, 11α-hydroxytormentic acid, 2α-methoxyursolic acid, 6-methoxy-β-glucopyranosyl ester, tormentic acid and 5α-diol 3-O-β-d-glucopyranosides were determined [31]. In addition to avonoids, triterpenoids eucaphic acid, nigaikigoside, betulinic acid, kajiikigoside, rubusid, tomentic acid and rosamutin were obtained from Rosa laevigata roots [32].…”

Section: Discussionmentioning

confidence: 99%

Application of Box-Behnken design for optimization of betulinic acid, ursolic acid and phenolics extraction from endemic Rosa psiformis subsp. pisiformis in relation to its cytotoxic activities

Demiray,

Dibek,

Özel

2024

Preprint

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Although it has important pharmacological bioactivities, betulinic acid is still obtained by extraction from wood heart and bark and by transformation synthetically. With these methods, less than 3% efficiency is obtained. Our endemic rose species, Rosa pisiformis (Christ.) D. Sosn., which is a new alternative source of betulinic acid and traditionally used for its medicinal properties, was collected from the province of Gümüşhane, its natural distribution, and organs of the plant such as root, stem, leaf and fruit were air diried and pulverizated. The drugs are extracted separately with three solvents (methanol, dichloromethane and hexane) with Box-Behnken optimized extraction method and the amounts of quercetin, rutin, catechin and betulinic, ursolic and oleanolic acids in roots, stems, leaves and fruits are determined with standard substances using HPLC-DAD techniques. According to the Box-Benchen method optimisation data was obtained as 65% ratio of solvent and 5 times maceration with 75 ml of solvents. By the way the highest amount of catechin was found in the leaf (DCM) as 15.61 µg/ml; stem was found to be rich in rutin (28.96 µg/ml) and quercetin (39.90 µg/ml). The amount of betulinic acid in stem (hexane) (11.84 µg/ml) and root (9.32 µg/ml) has been determined for the first time, and their cytotoxic activities were determined mostly in stem also leaves and roots followed this subsequently against prostate and lung carcinoma cells by ABTS-assay.

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Section: Discussionmentioning

confidence: 99%

Application of Box-Behnken design for optimization of betulinic acid, ursolic acid and phenolics extraction from endemic Rosa psiformis subsp. pisiformis in relation to its cytotoxic activities

Demiray,

Dibek,

Özel

2024

Preprint

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“…Analyses of secondary metabolites so far carried out in Rosa sp. were related to the pharmaceutical use of roses 15,16 . However, only little information is available about phytoalexins in roses.…”

Section: Introductionmentioning

confidence: 99%

Rhizosphere microbial communities associated to rose replant disease: links to plant growth and root metabolites

et al. 2020

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Growth depression of Rosa plants at sites previously used to cultivate the same or closely related species is a typical symptom of rose replant disease (RRD). Currently, limited information is available on the causes and the etiology of RRD compared to apple replant disease (ARD). Thus, this study aimed at analyzing growth characteristics, root morphology, and root metabolites, as well as microbial communities in the rhizosphere of the susceptible rootstock Rosa corymbifera 'Laxa' grown in RRD-affected soil from two sites (Heidgraben and Sangerhausen), either untreated or disinfected by γ-irradiation. In a greenhouse bioassay, plants developed significantly more biomass in the γ-irradiated than in the untreated soils of both sites. Several plant metabolites detected in R. corymbifera 'Laxa' roots were site-and treatment-dependent. Although aloesin was recorded in significantly higher concentrations in untreated than in γirradiated soils from Heidgraben, the concentrations of phenylalanine were significantly lower in roots from untreated soil of both sites. Rhizosphere microbial communities of 8-week-old plants were studied by sequencing of 16S rRNA, ITS, and cox gene fragments amplified from total community DNA. Supported by microscopic observations, sequences affiliated to the bacterial genus Streptomyces and the fungal genus Nectria were identified as potential causal agents of RRD in the soils investigated. The relative abundance of oomycetes belonging to the genus Pythiogeton showed a negative correlation to the growth of the plants. Overall, the RRD symptoms, the effects of soil treatments on the composition of the rhizosphere microbial community revealed striking similarities to findings related to ARD.

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“…[17] R laevigata is a climbing shrub originating from South China and Southeast Asia, and its fruit has been used to treat frequent urination, urinary incontinence, and sexual dysfunction in traditional Chinese and Korean medicine. [18,19] R Laevigata reportedly decreases the voiding frequency and increases the inter-micturition interval and urine volume by inhibiting smooth muscle contraction in a mouse pollakiuria model. [20] Furthermore, R laevigata has been shown as one of the most potent 5α-reductase inhibitors in a screening assay for anti-5α-reductase, including 162 plants.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of HT080 for lower urinary tract symptoms associated with benign prostatic hyperplasia

2019

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Background:Lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) are one of the most common conditions seen in middle-aged and elderly men and threaten their quality of life. Since conventional pharmacotherapy for LUTS/BPH can lead to sexual side effects, herbal therapies are widely used as complementary and alternative treatments worldwide. HT080 is an herbal extract of Cinnamomum cassia and Rosa Laevigata, both of which have been used to treat symptoms typically associated with BPH in traditional Asian medicine. The aims of this trial are to assess whether HT080 can alleviate LUTS/BPH in middle-aged and elderly men, and to investigate the safety of HT080.Methods/design:A double-blind, randomized, placebo-controlled, two-arm parallel group trial will be conducted in men with moderate LUTS/BPH. A total of 100 eligible men aged 40 to 75 years with an International Prostate Symptom Score of 8 to 19 will be randomized in a 1:1 ratio and receive either HT080 (500 mg) or placebo twice a day for 12 weeks. All participants will be evaluated for efficacy and safety at baseline and weeks 6 and 12. The primary endpoint is the change in International Prostate Symptom Score between baseline and week 12. The secondary efficacy variables are uroflowmetry parameters (maximal urinary flow rate and post-void residual volume), serum prostate-specific antigen, testosterone, and dihydrotestosterone levels, the International Index of Erectile Function score, and participant-reported global response assessment scores. The safety assessments include adverse events, laboratory tests results, vital signs, and physical examination.Discussion:This is a first-in human trial designed to investigate the efficacy and safety of HT080 among middle-aged and elderly men with LUTS/BPH. This prospective study with a double-blind randomized design will provide high-quality evidence supporting the use of HT080 for LUTS/BPH.Trial registration:Korean Clinical Research Information Service (KCT0004286) Registered September 6, 2019.

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A Review on Secondary Metabolites of Rosa laevigata Michaux: An Important Medicinal Plant

Cited by 7 publications

References 14 publications

Application of Box-Behnken design for optimization of betulinic acid, ursolic acid and phenolics extraction from endemic Rosa psiformis subsp. pisiformis in relation to its cytotoxic activities

Application of Box-Behnken design for optimization of betulinic acid, ursolic acid and phenolics extraction from endemic Rosa psiformis subsp. pisiformis in relation to its cytotoxic activities

Rhizosphere microbial communities associated to rose replant disease: links to plant growth and root metabolites

Efficacy and safety of HT080 for lower urinary tract symptoms associated with benign prostatic hyperplasia

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