The popularity of electronic cigarettes (e-cigarettes) is rapidly increasing in many countries. These devices are designed to imitate regular cigarettes, delivering nicotine via inhalation without combusting tobacco but currently, there is a lack of scientific evidence on the presence or absence of nicotine exposure. Such research relies on evidence from e-cigarette users urine samples. In this study, we aimed to determine the levels and compare the amount of nicotine to which e-cigarette users, cigarette smokers and passive smokers are exposed. Therefore, urine samples were collected from e-cigarette users, cigarette smokers, passive smokers, and healthy nonsmokers. The urinary cotinine levels of the subjects were determined using gas chromatography-mass spectrometry. The mean (±SD) urinary cotinine levels were determined as 1755 ± 1848 ng/g creatinine for 32 e-cigarette users, 1720 ± 1335 ng/g creatinine for 33 cigarette smokers and 81.42 ± 97.90 ng/g creatinine for 33 passive smokers. A significant difference has been found between cotinine levels of e-cigarette users and passive smokers (p < 0.05). There were no statistically significant differences between e-cigarette users and cigarette smokers (p > 0.05). This is a seminal study to demonstrate the e-cigarette users are exposed to nicotine as much as cigarette smokers.

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In recent years, ecotoxicological studies have been conducted around the world, especially in aquatic ecosystems. It is noteworthy that genotoxicity tests have been frequently used in the biomonitoring of pollution. The present study evaluates genotoxicity tests including comet assays, micronucleus assays, fluorescent in-situ hybridization assays, chromosomal aberration assays, and sister chromatid exchange assays used in fish species for biomonitoring of environmental pollution in Turkey. Thirty-six ecotoxicological studies, which aimed to investigate possible genotoxic damage in fish species between the years 1970 and 2016, were analyzed. As a result of the literature review, it was concluded that the largest number of studies were done in 2011. There were micronucleus assays in 83.33%, comet assays in 30.55%, chromosomal aberration assays in 5.55%, and sister chromatid exchange experiments in 2.77% of the studies. Most of the micronucleus experiments were performed in eco-genotoxicological studies. Our results show that there were no statistically significant differences (p>0.05) between the erythrocyte and gill samples in the micronucleus results from the studies. This study is the first assessment of the use of genotoxicity tests in ecotoxicological studies in Turkey. Considering the principle of refinement in 4 R theory our results show that the use of gill cells instead of peripheral erythrocytes would be more appropriate in micronucleus assays.

Obesity is considered as a disease, which affects the whole world. Recent years, epidemiological studies linking obesity with increased risk of cancer is steadily increasing. Studies suggest that obesity might be a risk for genotoxic damage. Obesity-associated genotoxic damage can initiator, promote cancer growth by favoring cancer cell proliferation and migration, and blocking to apoptosis. Obesity can change the repair mechanism of DNA chain breaks. In addition, the increase in oxidative stress and inflammation associated with obesity could increase DNA damage and prevent DNA functioning mechanisms, resulting in DNA damage transformation into a cancerous cell. Studies over the past few years have shown that obesity can affect genome stability. In this review article, the genotoxic effects of obesity are explained in detail.

Obesity is so common within the world's population and prevalence has increased markedly over. And we know that toxic chemical substance exposure increased that both of obesity prevalence and formation of health problems related with obesity. Nuclear receptors that are sensors of exposure to xenobiotics. In addition recent studies have proposed a first set of obesogens that target nuclear hormone receptor signaling pathways with relevance to adipocyte biology and the developmental origins of health and disease. In this paper assesses the information about a huge puclic helath problem that is obesity and its relationship also evaluated that nuclear receptor signaling pathways of obesogens.

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