Objective To evaluate the changing trends in dermatology clinical practice at a tertiary center during the coronavirus disease 2019 (COVID‐19) pandemic. Method This retrospective cohort study was conducted on patients who were admitted to Ufuk University Hospital with dermatologic complaints/diseases before and during the pandemic. The patients were divided into two groups: 1) the Pre‐pandemic period (March‐May 2019) and 2) the Pandemic period (March‐May 2020). Demographic features, clinical characteristics, dermatologic diseases/complaints, dermatologic procedures/interventions, hospitalization rate, and use of biologic agents were compared between the two groups. Results Total number of hospital admissions have decreased from 1165 to 717. Admission rates for acne, dermatophytosis, and benign neoplasm of the skin significantly lower during the pandemic period (p values were 0.02, 0.04, and 0.006, respectively). Contact dermatitis, acne accompanying dermatitis, cicatricial hair loss, lichen planus, and zona zoster infection rates were significantly higher (p values were 0.007, <0.001, 0.009, 0.04 and 0.03, respectively). Rates of biopsy and electrocautery procedures were decreased significantly (p values were <0.001 and 0.002, respectively). The hospitalization rate was similar between the groups (p=0.51). However, the use of biologic agents significantly decreased during the pandemic period (p=0.01). Conclusion Updated clinical protocols should be established for the new normal period in accordance with these findings. This article is protected by copyright. All rights reserved.

Background: Lasers have great importance in the management of vascular skin lesions.Aim: To determine the efficacy of 577-nm pro-yellow laser in cure of certain vascular skin diseases.Material and methods: Seventy-four patients who are diagnosed as vascular skin diseases were involved in this study. All participants were treated with 577-nm proyellow laser with 4-week intervals. The photographs that were taken before and at every following visit were used to evaluate improvement.Results: A significant improvement occurred in port-wine stain, rosacea, facial telangiectasia, venous lake, scrotal angiokeratoma, and cherry angioma cases. Conclusion:Vascular skin lesions can be treated with 577-nm pro-yellow laser with a minimal adverse effect and great success rate.

Objective: Telogen effluvium is one of the chronic diseases that affect the quality of life (QoL) in women. The study aimed to evaluate the RDW/MCV ratio and its correlation with ferritin in Telogen Effluvium patients and to reveal their potential role in the etiopathogenesis of Telogen effluvium. Material and Methods: We retrospectively evaluated the medical data of 250 patients who were admitted to the dermatology outpatient clinic between September 2020 and December 2020 with a diagnosis of Telogen effluvium. The control group was created retrospectively from the medical records of 250 healthy individuals. HB, HCT, MPV, MCV, RDW, ferritin, and MCV/RDW ratio of both groups were compared and evaluated statistically. Results: All of the Telogen effluvium patients were women in terms of gender. The mean age of the patient group was 33,11±9,66 years and the mean age of the control group was 34,98±12,37 years. The ratio of MCV/RDW, MPV, MCV, and ferritin is lower in the group with Telogen effluvium compared to the control group and a statistically significant difference was found(p<0.05). However, the correlation between MCV/RDW ratio and ferritin was evaluated in Telogen effluvium patients, and no significant differences were found (p>0.05). Conclusion: Iron deficiency anemia is thought of as a factor in female patients with telogen effluvium. Although the data shows the correction of iron deficiency is insufficient telogen effluvium, we proposed that laboratory tests should be routinely used in the diagnosis and treatment phase of patients who apply with the complaint of hair loss.

Onychocryptosis, frequently termed ''ingrown toenail'' is a common foot problem in routine dermatology and orthopaedic clinical practice which leads to pain and disability. [1][2][3] Although the aetiology of ingrown toenail is not well understood various associated risk factors have been identified with the pathogenesis. 4 It is known that there is an association between hallux valgus angle (HVA) and ingrown toenail, it has been reported that increased HVA in the patients with ingrown toenail.The objective of this study was to analyse the relationship between the HVA and intermetatarsal angle (IMA) with the ingrown toenail. There were 121 female and 49 male patients in the case group and 68 female and 32 male in the control group. The mean age of the case group was 41.1 years and 41.1 years in control group. A statistically significant difference was found between the case and the control groups in terms of right HVA variable. In this article we found that IMA has an association with ingrown toenail, too. The Xrays of the feet should be performed to determine the susceptibility of the patients who are admitted to the hospital for ingrown toenail in order to prevent other toe ingrown toenail and for planning the treatment of the patients with ingrown toenail.

Objective Acne vulgaris is a multifactorial disease of the pilosebaceous unit. As the most common skin disease, it may affect approximately 85% of the young population. Survivin, a member of the inhibitors of the apoptosis (IAP) gene family, can inhibit apoptosis and regulate cell division and proliferation. In the study, we aimed to investigate the potential role of serum survivin in acne vulgaris. Methods Forty individuals who were diagnosed with acne vulgaris and forty healthy subjects as the control group were enrolled in the study. Venous blood samples were collected from each participant, and the serum levels of survivin were measured by enzyme‐linked immunosorbent assay (ELISA). Statistical analysis was performed using SPSS software version 25. Results The serum survivin levels were statistically significant between the groups, and the levels of survivin were measured as acne vulgaris patients group 153.44 and control group 104.17 pg/ml, respectively (p < 0.018). When the serum survivin levels were compared according to gender, females had higher levels of survivin than the males (168.16 versus 50.45 pg/mL, p = 0.001). A significant correlation was found between acne severity (p = 0.017) and Scale for Acne Scar severity (SCAR‐S) score (p = 0.001) according to the survivin levels. In terms of age, no significant relationship was found between age and survivin (p = 0.4048). Conclusion Elevated serum levels of survivin were determined in acne vulgaris. Moreover, there was a significant correlation between acne stage and SCAR‐S score according to survivin levels.

The objective of this paper is to evaluate the attitudes of patients with various dermatologic diseases towards coronavirus disease (COVID-19) vaccines. The present questionnaire-based study was conducted on patients admitted to the outpatient clinic of the Department of Dermatology and Venereology, Ufuk University Hospital, between January 1 and 31, 2021. The study population was divided into two groups based on their ages: (1) < 40 age group ( n = 188) and (2) ≥ 40 age group ( n = 111), and answers given to 35 specific questions were compared between the groups. The older group had significantly higher levels of anxiety compared to the younger group ( p = 0.017). Although approximately 60% of cases in the older group were dedicated to being vaccinated, 40% of the younger participants were not sure about vaccination ( p < 0.001). The most frequently demanded vaccine types were the inactivated and mRNA vaccines in the elderly and young groups, respectively ( p < 0.001). Statistically significant positive weak correlations were observed for age, chronic disease of medication, and presence of severe COVID 19 cases in the environment ( r = 0.125 p = 0.031, r = 0.184 p = 0.001, r = 0.122 p = 0.035, respectively). Dermatologic patients had generally positive attitudes towards COVID-19 vaccination, and their preferences were affected by age.

Aim of the study is to compare efficacy of targeted broad‐band UVB phototherapy and topical psoralen with targeted UVA phototherapy treatments in localized vitiligo for 3 months prospectively. The cases with symmetrical vitiligo lesions were included in the study. Broad‐band targeted UVB was applied on one side and targeted UVA phototherapy with topical psoralen on the other side. Twenty‐two patients who were diagnosed with localized vitiligo were enrolled in this study. These cases consisted of 6 (27.3%) females and 16 (72.7%) males aging between 17 and 69 (34.22 ± 14.15). Fifty‐four lesions (27 left, 27 right) were compared for treatments. After the first month of the treatments, the sides of the lesions were compared in order to evaluate improvement. Percentages of success were 25% for targeted broad‐band UVB microphototherapy and 75% for topical psoralen with targeted UVA microphototherapy. When the two treatment methods were compared with each other, a significant difference was found in terms of treatment response (P = .017). At the end of the third month, the success rates were 37.5% for targeted broad‐band UVB microphototherapy and 62.5% for topical psoralen with targeted UVA microphototherapy, however a statistically significant difference was not determined between the two treatments (P > .05). Both targeted broad‐band UVB phototherapy and topical psoralen with targeted UVA phototherapy provided repigmentation for localized vitiligo at the end of the third month. Our investigation shows that both treatments are safe and they provide repigmentation with a limited response.

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